| 李 英,董 良,李海金.非小细胞肺癌血清VEGF、bFGF和TNF-α的临床意义[J].肿瘤学杂志,2013,19(1):50-54. |
| 非小细胞肺癌血清VEGF、bFGF和TNF-α的临床意义 |
| The Clinical Significance of Serum VEGF，bFGF and TNF-?琢 in Non-small Cell Lung Cancer |
| 投稿时间：2012-09-10 |
| DOI：10.11735/j.issn.1671-170X.2013.01.B2012450 |
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| 中文关键词: 癌，非小细胞肺 血管内皮生长因子 碱性成纤维细胞生长因子 肿瘤坏死因子α |
| 英文关键词:carcinoma,non-small cell lung vascular endothelial growth factor basic fibroblast growth factor tumor necrosis factor-a |
| 基金项目:浙江省医学会临床科研基金项目（2009ZYC43） |
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| 摘要点击次数: 2099 |
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| 中文摘要: |
| 摘 要: ［目的］ 观察非小细胞肺癌（NSCLC）患者血清血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）和肿瘤坏死因子a(TNF-a）与NSCLC临床特征的相关性，探讨三者在NSCLC疗效评价中的临床价值。［方法］ 采用双抗体夹心酶联免疫吸附法（ELISA）检测NSCLC患者化疗前1d、化疗结束1周后血清VEGF、bFGF和TNF-a的含量。 ［结果］ NSCLC患者化疗前血清VEGF、bFGF和TNF-a与患者临床分期有关（P＜0.05），与患者年龄、性别及病理类型无关；分析68例晚期NSCLC患者化疗前后血清VEGF、bFGF和TNF-a的变化，临床获益组与疾病进展组比较三者均有明显下降（P＜0.05）。［结论］ 血清VEGF、bFGF和TNF-a与NSCLC肿瘤负荷有关；血清VEGF、bFGF和TNF-?琢水平可作为NSCLC患者化疗疗效预测的参考指标。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the levels of serous vascular endothelial growth factor (VEGF)，basic fibroblast growth factor (bFGF)，and tumor necrosis factor-a (TNF-a) in patients with non-small cell lung cancer(NSCLC) and their relationships with clinical characteristics，and their clinical significance in the evaluation of treatment outcomes were studied.［Methods］ The levels of serous VEGF，bFGF and TNF-a were detected by enzyme-linked immunosorbent assay (ELISA) in NSCLC patients before chemotherapy and one week after chemotherapy. ［Results］ Serous VEGF，bFGF and TNF-a before chemotherapy were correlated with clinical stage(P<0.05)，but not with age，gender and pathological type. Among 68 patients with advance NSCLC，the levels of serous VEGF，bFGF and TNF-a declined significantly after chemotherapy in clinical benefit patients than those in patients with progressive disease (PD) (P<0.05). ［Conclusion］ Serous VEGF，bFGF and TNF-a are related to the cancer load in NSCLC patients. Serous VEGF，bFGF and TNF-a might be helpful in predicting of chemotherapeutic response. |
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