| 袁 霞,李金高,黄 敏.血浆可溶性c-Met水平在鼻咽癌患者中的临床意义[J].肿瘤学杂志,2013,19(3):179-182. |
| 血浆可溶性c-Met水平在鼻咽癌患者中的临床意义 |
| Clinical Significance of Plasma Soluble c-Met in Nasopharyngeal Carcinoma |
| 投稿时间：2012-08-27 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012412 |
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| 中文关键词: 可溶性c-Met 鼻咽肿瘤 ROC 曲线 |
| 英文关键词:soluble c-Met nasopharyngeal neoplasms ROC curve |
| 基金项目:江西省卫生厅资助课题 (20123105) |
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| 中文摘要: |
| 摘 要：［目的］ 探讨肝细胞生长因子受体(c-Met)可溶性形式(sMet)在鼻咽癌患者血浆中的水平变化及临床意义。［方法］ 收集84例鼻咽癌患者和84名正常人的血浆标本，ELISA检测血浆中sMet水平，并以ROC曲线评价sMet水平对鼻咽癌发生风险的临床预测价值。［结果］ 鼻咽癌Ⅰ~Ⅱ期患者血浆中sMet的水平［（293.6±15.8）ng/ml］及鼻咽癌Ⅲ~Ⅳ期患者血浆中sMet的水平［（343.8±12.6）ng/ml］分别为正常对照组表达水平［（224.2±13.5）ng/ml］的1.31、1.53倍（P<0.01）。ROC曲线分析显示，血浆sMet水平和发生鼻咽癌的风险存在密切相关性，具有明显的临床诊断价值。［结论］ sMet可能是鼻咽癌早期诊断的一个潜在的血浆标志物。 |
| 英文摘要: |
| Abstract: ［Purpose］ To study the plasma level of soluble c-Met (sMet) in patients with nasopharyngeal carcinoma (NPC) and its clinical significance. ［Methods］ The prospective study was performed by using plasma derived from 84 NPC cases and 84 normal controls. Plasma concentration of sMet was measured by specific enzyme-linked immunosorbent assay. Data were analyzed by SPSS software，and the predictive values were determined based on the ROC curves analysis. ［Results］ Plasma concentrations of sMet were (293.6±15.8)ng/ml and (343.8±12.6)ng/ml in patients with NPC stage Ⅰ~Ⅱ and stage Ⅲ~Ⅳ，respectively. Plasma concentration of sMet in patients with NPC was significantly higher than that in normal controls（224.2±13.5）ng/ml(P<0.01).The ROC curve analysis revealed a significant correlation between plasma sMet level and the risk of NPC. ［Conclusion］ Plasma sMet could serve as a potential biomarker for predicting NPC at early stage. |
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