| 任 庆,田秀荣,王鸿智.介入联合同期放化疗治疗局部晚期鼻咽癌的临床研究[J].肿瘤学杂志,2013,19(3):171-174. |
| 介入联合同期放化疗治疗局部晚期鼻咽癌的临床研究 |
| A Clinical Trial of Transcatheter Superselective Intra-arterial Chemotherapy Combined with Concurrent Chemoradiotherapy in the Treatment for Advanced Nasopharyngeal Carcinoma |
| 投稿时间：2012-07-30 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012375 |
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| 中文关键词: 鼻咽肿瘤 经导管超选择动脉灌注化疗 同期放化疗 |
| 英文关键词:nasopharyngeal neoplasms transcatheter superselective intra?鄄arterial chemotherapy concurrent chemoradiotherapy |
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| 摘要点击次数: 1804 |
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| 中文摘要: |
| 摘 要:［目的］ 探讨介入联合同期放化疗治疗局部晚期鼻咽癌的疗效。［方法］ 收集108例初治局部晚期鼻咽癌患者（Ⅲ～Ⅳa期），分为介入联合同期放化疗组（研究组）以及同期放化疗组（对照组）。观察并比较两组的近、远期疗效和不良反应。［结果］ 研究组与对照组的治疗总有效率分别为92.7%和79.2%，差异有统计学意义（P=0.04）。研究组3年生存率为98.2%，对照组为96.2%；3年复发率分别为9.1%与17.0%，远处转移率分别为5.5%与13.2%，差异均无统计学意义（P>0.05）。两组急性不良反应比较亦无显著性差异。［结论］ 介入联合同期放化疗治疗局部晚期鼻咽癌，对比同期放化疗，近期疗效有所提高，急性不良反应相似。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the effect of transcatheter superselective intra-arterial chemotherapy combined with concurrent chemoradiotherapy in the treatment for advanced nasopharyngeal carcinoma. ［Methods］ A total of 108 patients with advanced nasopharyngeal carcinoma（stage Ⅲ～Ⅳa） were enrolled in this study，and were divided into transcatheter superselective intra-arterial chemotherapy combined with concurrent chemoradiotherapy group(research group) and concurrent chemoradiotherapy group(control group)．The clinical efficacy and side effects were observed and compared between the two groups. ［Results］ The response rates of research group and control group were 92.7％ and 79.2%，respectively，with significant difference(P=0.04). The 3-year survival rates of research group and control group were 98.2% and 96.2%; 3-year local recurrent rates were 9.1% and 17.0%; the distant metastasis rates were 5.5% and 13.2%. None of them had significant difference between two groups. The degree of acute toxicity between two groups was similar，also without significant difference．［Conclusion］ Compared with concurrent chemoradiotherapy alone，the selective arterial chemotherapy combined with concurrent chemoradiotherapy is benefit in short-term response in the treatment for advanced nasopharyngeal carcinoma， but the acute toxi-city is similar between the two groups. |
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