| 李建成,陈 诚,潘建基.不同肺体积定义对肺癌放疗剂量学的影响[J].肿瘤学杂志,2013,19(4):263-267. |
| 不同肺体积定义对肺癌放疗剂量学的影响 |
| Effect of Different Definition for Lung Volume on the Radiation Dosimetry for Lung Cancer |
| 投稿时间：2012-04-25 |
| DOI：10.11735/j.issn.1671-170X.2013.04.B2012206 |
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| 中文关键词: 肺肿瘤 放射疗法 正常肺体积 放射剂量学 |
| 英文关键词:lung neoplasms radiotherapy normal lung volume radiodosimetry |
| 基金项目:福建省临床重点专科建设项目（2012年） |
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| 中文摘要: |
| 摘 要：［目的］ 评估不同的正常肺体积定义对肺癌放疗计划的肺剂量学影响。［方法］ 收集接受放射治疗的肺癌患者20例，均用CT模拟定位。勾画肺癌靶区GTV、CTV、PTV-GTV、PTV-CTV及危及器官（OAR）。正常肺体积按4种定义分别勾画，A组：双肺体积包含GTV；B组：双肺体积减去GTV；C组：双肺体积减去CTV；D组：双肺体积减去PTV-GTV。获取不同肺体积定义的肺剂量学参数值V5、V20、MLD，以B组为对照组分别与其余三组配对比较肺的剂量学参数。［结果］ 不同肺体积定义会导致肺剂量参数值显著变化（P值均小于0.000），各参数值变化幅度与GTV大小呈正相关，其中肺V20相关性较V5及MLD强。当以GTV/双侧肺体积代表GTV因素时，能更好地反映GTV大小对肺剂量参数指标的影响。［结论］ 肺癌靶区勾画中肺体积的不同定义影响正常肺剂量学。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the effect of different definition for lung volume on the radiation dosimetry for lung cancer. ［Methods］ Twenty patients with lung cancer were treated with intensity modulated radiation therapy，and the GTV，CTV，PTV of primary tumor and organs at risk were delineated. Normal lung volumes with different definitions were divided into four groups，and the differences of V20，V5 and MLD were analyzed by paired t-test. ［Results］ The parameters varied considerably with different definitions of lung volume and the rangeability positively correlated with GTV，especially the V20. When GTV/lung volume represented the GTV，the effect of GTV on the lung dosimetric parameters would be better presented.［Conclusion］ Different definitions of lung volume have an effect on the lung dosimetric parameters. |
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