| 丁小文,莫文菊,陈 杰.乳腺癌新辅助化疗后前哨淋巴结活检的研究[J].肿瘤学杂志,2012,18(12):935-938. |
| 乳腺癌新辅助化疗后前哨淋巴结活检的研究 |
| Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy for Breast Cancer Patients |
| 投稿时间：2012-09-10 |
| DOI： |
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| 中文关键词: 乳腺肿瘤 前哨淋巴结活检 新辅助化疗 腋窝淋巴结清扫 |
| 英文关键词:breast neoplasms sentinel lymph node biopsy(SLNB) neoadjuvant chemotherapy axillary lymph nodes dissection(ALND) |
| 基金项目:浙江省卫生厅医药卫生科技项目（2009B031） |
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| 中文摘要: |
| 摘 要:［目的］ 研究乳腺癌新辅助化疗后行前哨淋巴结活检(SLNB)的准确性、可行性。［方法］比较接受新辅助化疗的乳腺癌和未接受新辅助化疗乳腺癌SLNB的成功率、灵敏度、假阴性率、准确性，以及SLNB、腋窝淋巴结清扫(ALND)淋巴结检出枚数，同时对影响SLNB的因素进行讨论。［结果］ 26例新辅助化疗后乳腺癌SLNB的成功率、灵敏度、假阴性率、准确性分别为92.3%、90.9%、9.1%和95.8%，SLNB和ALND平均检出淋巴结分别为1.5、13.5枚，对比非新辅助化疗病例，均无明显统计学差异。肿瘤的位置、多灶性、前哨淋巴结的数量等可能是影响乳腺癌新辅助化疗后SLNB的因素。［结论］ 乳腺癌新辅助化疗后SLNB基本上是安全可行的。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the feasibility and accuracy of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy for patients with breast cancer.［Methods］ The differences of identified rate，sensitivity，false-negative rate，accuracy of SLNB，and the number of lymph nodes of SLNB and axillary lymph nodes dissection(ALND) between neoadjuvant group and non-neoadjuvant group were compared，and influencing factors for SLNB were discussed.［Results］ A total of 26 patients with neoadjuvant chemotherapy followed by SLNB were enrolled. The SLN identified rate，sensitivity，false-negative rate and accuracy were 92.3%，90.9%，9.1% and 95.8%，respectively. The number of lymph nodes of SLNB and ALND was 1.5 and 13.5，respectively.There was no significant difference in these indicators between neoadjuvant group and non-neoadjuvant group. Location of the tumor，multicentric disease and number of SLN might be important factors affecting SLNB after neoadjuvant chemotherapy for breast cancer. ［Conclusions］ SLNB is feasible and applicable for patients with operable breast disease who have received neoadjuvant chemotherapy. |
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