| 郑中显,徐金发,宋文灿.分次立体定向放射治疗全脑放疗后肺癌脑转移瘤52例疗效分析[J].肿瘤学杂志,2012,18(11):819-822. |
| 分次立体定向放射治疗全脑放疗后肺癌脑转移瘤52例疗效分析 |
| Efficacy of Fractionated Stereotactic Radiotherapy for 52 Cases with Brain Metastasis from Lung Cancer After Whole Brain Radiotherapy |
| 投稿时间：2012-05-22 |
| DOI： |
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| 中文关键词: 分次立体定向放射治疗 脑转移瘤 肺肿瘤 |
| 英文关键词:fractionated stereotactic radiotherapy brain metastasis lung neoplasms |
| 基金项目:安徽省池州市科技计划项目（ZC09008） |
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| 中文摘要: |
| 摘 要：［目的］ 分析分次立体定向放射治疗全脑放疗后肺癌脑转移瘤的疗效及不良反应。［方法］ 2007年12月至2010年12月对KPS>60分的52例全脑放疗后的肺癌脑转移（病灶数目少于4个）患者给予分次立体放射治疗，单次靶区周边剂量为3~5Gy，总剂量为15~25Gy，分3~5次完成，50%等剂量曲线包绕PTV。［结果］ 截至2011年12月，46例患者死亡。自再次放疗开始算起，全组中位生存期为10.7个月（95%CI为8.5~12.9），1年及2年生存率分别为28.4%和7.2%。全组临床症状缓解率为73.1%，肿瘤局部控制率为90.4%。仅1例患者出现放射性脑坏死。［结论］ 分次立体定向放射治疗用于全脑放疗后疾病进展的肺癌脑转移患者，可以提高生存质量、延长患者生存期，安全性较好，但需严格掌握适应证。 |
| 英文摘要: |
| Abstract:［Purpose］ To evaluate the efficacy and toxicity of fractionated stereotactic radiotherapy (FSRT) on brain metastasis from lung cancer after whole brain radiotherapy. ［Methods］ From December 2007 to December 2010，52 cases with KPS>60 and 1～4 brain metastases from lung cancer were treated with FSRT after whole brain radiotherapy. A total of radiation dose of 15Gy to 25Gy was prescribed，3Gy to 5Gy per fraction / 3 to 5 fractions，with 50% of dosage curve covering the target edge. ［Results］ Up to December 2011，46 death events occurred. After irradiation，median overall survival was 10.7 months（95%CI，8.5～12.9），the rates of 1-year and 2-year overall survival were 28.4% and 7.2%，respectively. The clinical symptoms remission rate was 73.1% and local tumor control rate was 90.4% for all patients. Only one patient experienced asymptomatic brain radionecrosis. ［Conclusion］ FSRT for brain metastasis from lung cancer after whole brain radiotherapy resulted in improved quality of life and prolonged survival with acceptable safety profiles，but strict indications should be considered. |
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