| 郑放超,张小玉,冯怀志.体部伽玛刀联合DC-CIK过继免疫治疗晚期非小细胞肺癌的疗效观察[J].肿瘤学杂志,2012,18(11):815-818. |
| 体部伽玛刀联合DC-CIK过继免疫治疗晚期非小细胞肺癌的疗效观察 |
| Clinical Study of Stereotactic Conformal Body γ-knife Combined with Adoptive Immunotherapy (Dendritic Cell and Cytokine-induced Killer Cell) in the Treatment for Advanced Non-small Cell Lung Cancer |
| 投稿时间：2012-02-07 |
| DOI： |
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| 中文关键词: 癌，非小细胞肺 立体定向放射治疗 树突状细胞 细胞因子诱导杀伤细胞 伽玛刀 |
| 英文关键词:carcinoma,non-small cell lung stereotactic conformal therapy dendritic cells |
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| 中文摘要: |
| 摘 要:［目的］ 研究立体定向体部伽玛刀配合过继免疫治疗晚期非小细胞癌(NSCLC)的临床疗效和意义。［方法］ 选择72例晚期NSCLC患者，随机分为两组：放疗组36例，接受体部伽玛刀治疗；联合组36例，除给予伽玛刀治疗外，还接受自体树突状细胞(DC)和细胞因子诱导的杀伤细胞(CIK)的过继免疫治疗，比较两组患者治疗后的免疫功能、生活质量及生存情况等。［结果］ 治疗后3个月，联合组患者外周血CD3+CD56+阳性率、Th1/Th2比值、Ag-NOR比值等免疫学指标均高于放疗组（P<0.05）；联合组患者生活质量（PS评分）、肝功能（ALT）、血清肿瘤标志物（CEA和CA125）等指标均较放疗组患者降低（P<0.05）；另外，联合组患者的6个月疗效、中位生存时间均优于放疗组（P<0.05）;联合组白细胞降低和全身乏力的发生率低于放疗组（P<0.05）。［结论］ 立体定向伽玛刀联合DC-CIK过继免疫治疗能改善晚期NSCLC患者的免疫功能和生活质量，降低不良反应发生率，提高临床疗效。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the clinical effect of stereotactic conformal body gamma (γ)-knife combined with adoptive immunotherapy in the treatment for advanced non-small cell lung cancer (NSCLC). ［Methods］ Seventy-two patients with advanced NSCLC were divided into two groups randomly. Thirty-six patients of radiotherapy group were treated with stereotactic conformal body γ-knife alone and other 36 patients of joint group were treated with stereotactic conformal body γ-knife combined with adoptive immunotherapy (dendritic cell and cytokine induced killer cell，DC-CIK). The therapeutic effect was compared between two groups. ［Results］ Three months after treatment，immunological indicators including positive rate of CD3+CD56+，Th1/Th2 ratio and Ag-NOR ratio in patients of joint group were higher than those in patients of radiotherapy group (P<0.05). Also，the PS score，ALT，CEA and CA125 were lower in patients of joint group than those in patients of radiotherapy group (P<0.05). The median survival time of joint group was longer than that of radiotherapy group (P<0.05). The incidence rates of leukocytopenia and acratia were lower in joint group than those in radiotherapy group (P<0.05).［Conclusion］ Stereotactic conformal body γ-knife combined with DC-CIK can improve immunity function and QOL in patients with advanced NSCLC，and reduce the incidence rate of side effects. |
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