| 毕爱红,贾勇士,吴树强.肝内胆管细胞癌根治术的预后因素分析[J].肿瘤学杂志,2012,18(10):775-779. |
| 肝内胆管细胞癌根治术的预后因素分析 |
| Analysis of Prognostic Factors of Intrahepatic Cholangiocarcinoma After Radical Surgery |
| 投稿时间：2012-08-22 |
| DOI： |
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| 中文关键词: 肝内胆管细胞癌 手术治疗 微转移灶 预后 |
| 英文关键词:intrahepatic cholangiocarcinomas surgery micro-metastasis prognosis |
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| 摘要点击次数: 1425 |
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| 中文摘要: |
| 摘 要：［目的］ 分析影响肝内胆管细胞癌（IHC）根治术预后的因素。［方法］ 回顾性分析82例IHC患者的临床及病理资料，阅读病理切片，寻找显微镜下是否存在微转移灶。对所有患者进行定期随访，并行生存分析。［结果］ 82例IHC手术切除标本中，53例（64.6%）显微镜下可见微转移灶。存在微转移灶、γ-谷氨酰转肽酶(γ-GT)高、癌胚抗原（CEA）增高及有肝内结石或血吸虫等慢性肝病史是IHC的独立预后因素。［结论］ 镜下存在微转移灶、CEA增高、慢性肝病史、γ-GT升高是根治性切除后的IHC独立不良预后因素，根治术后应积极治疗。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the prognostic factors of intrahepatic cholangiocarcinomas (IHC) after radical surgery. ［Methods］ Eighty-two cases with IHC proven pathologically after radical surgery were enrolled. The micro-metastasis was found with microscope. All the patients were followed up. SPSS 17.0 was used for statistic analysis.［Results］ Fifty-three (64.6%) IHC patients had micro-metastasis. Both univariate analysis and multivariate analysis showed that micro-metastasis，intrahepatic calculi or liver fluke and serum higher γ-GT and CEA were independent prognostic factors (P<0.05). ［Conclusion］ Micro-metastasis，intrahepatic calculi or liver fluke and serum higher γ-GT and CEA are independent prognostic factors of IHC after radical surgery，and new treatment strategy should be made accordingly. |
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