| 叶淑芳,毛卫波,黄 渊.胃肠免疫标志物在胃印戒细胞癌中的表达意义[J].肿瘤学杂志,2012,18(10):753-756. |
| 胃肠免疫标志物在胃印戒细胞癌中的表达意义 |
| The Expression of Gastric and Intestinal Phenotypic Markers in Gastric Signet-ring Cell Carcinoma |
| 投稿时间：2012-05-09 |
| DOI： |
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| 中文关键词: 胃肿瘤 印戒细胞癌 免疫表型分型 免疫组织化学 |
| 英文关键词:gastric neoplasms signet-ring cell carcinoma immunophenotyping immounohistochemistry |
| 基金项目:丽水市科技计划项目（2010JYZB29） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胃肠免疫表型标志物在胃印戒细胞癌中的表达及其与临床病理特征的关系。［方法］ 免疫组织化学EnVision法检测94例胃印戒细胞癌中胃免疫表型标志物MUC1、MUC5AC和肠免疫表型标志物MUC2、CD10的表达。［结果］ 胃肠免疫表型标志物表达水平与印戒细胞癌形态学分型无关（P>0.05）。MUC2、CD10在进展期癌中阳性表达率均显著高于早期癌，差异有统计学意义（P<0.01）。MUC1、MUC5AC在进展期癌中的阳性表达率均低于早期癌，差异有统计学意义（P<0.05）。生存分析显示，胃型印戒细胞癌5年生存率明显高于肠型和混合型印戒细胞癌（P<0.05）。［结论］ 胃型印戒细胞癌的生物学行为和预后均较肠型和混合型印戒细胞癌好。胃肠免疫表型标志物对胃印戒细胞癌的治疗及预后评估有一定的指导意义。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of gastric and intestinal phenotypic markers in gastric signet-ring cell (SRC) carcinoma and its relationship with clinicopathologic features. ［Methods］ Gastric phenotypic markers (MUC1 and MUC5AC) and intestinal phenotypic markers (MUC2 and CD10) were detected by immunohistochemistry in 94 cases with SRC carcinoma. ［Results］ There was no significant association between the expression of gastric and intestinal phenotypic markers and the morphological classification of SRC carcinoma (P>0.05). The positive rates of MUC2 and CD10 in advanced gastric carcinoma were significantly higher than those in early gastric carcinoma (P＜0.01). On the other hand，the rates of MUC5AC and MUC1 expression in advanced gastric carcinoma were significantly lower than those in early gastric carcinoma (P＜0.05). The 5-year survival rate in patients with gastric type SRC carcinoma was higher than that in intestinal and mixed type SRC carcinoma(P＜0.05). ［Conclusions］ The intestinal type and mixed type SRC carcinoma have poorer biologic behavior and prognosis，as compared with the gastric type. Gastric and intestinal phenotypic markers may be useful in predicting prognosis and guiding treatment for patients with gastric signet-ring cell carcinoma. |
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