| 郭玉凤,张志伟,贺修胜.组织芯片检测p16蛋白在不同胃组织中的表达意义[J].肿瘤学杂志,2012,18(10):746-749. |
| 组织芯片检测p16蛋白在不同胃组织中的表达意义 |
| Significance of p16 Protein in Different Gastric Tissues Detected by Tissue Array |
| 投稿时间：2012-06-11 |
| DOI： |
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| 中文关键词: 胃肿瘤 p16蛋白 临床病理学 免疫组织化学 |
| 英文关键词:gastric neoplasms p16 protein clinicopathology immunohistochemistry |
| 基金项目:湖南省高校创新平台开放基金（10K052）；湖南省研究生科研创新项目（CX2010B380）；湖南省大学生研究性学习和创新性实验计划项目（CXSY-SJ-09007、CXSY-SJ-10192）；湖南省教育厅科研项目（11C1112）；衡阳市科技局科研项目（2011kj52、2011kj53） |
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| 中文摘要: |
| 摘 要：［目的］ 分析胃癌相关差异表达蛋白p16在不同胃组织中的表达意义，为临床早期发现胃癌及评估胃癌患者预后提供有价值的资料。［方法］ 采用免疫组织化学染色，检测胃组织芯片（包括正常胃黏膜、癌旁、非典型增生、胃癌及淋巴结转移癌组织）中p16蛋白的表达，分析其在胃癌组织中表达与临床病理特征的关系。［结果］ p16蛋白在正常胃黏膜、癌旁、非典型增生和胃癌组织中的表达率分别为76.47%（26/34）、79.59%（39/49）、34.62%（9/26）和8.64%（7/81）；p16蛋白在胃癌组织中阳性表达率较正常胃黏膜、癌旁组织和非典型增生组织降低（P<0.01），而非典型增生组织中阳性表达率较正常胃黏膜和癌旁组织降低（P<0.05）；p16蛋白表达与胃癌患者年龄、肿块大小和淋巴结转移有关（P<0.05）。［结论］ p16蛋白表达与胃癌的发生发展、患者年龄、肿块大小及淋巴结转移有关。 |
| 英文摘要: |
| Abstract: ［Purpose］ To analysis the expression of gastric cancer related differential expression protein p16 in various gastric tissues，and to provide valuable data for clinical early detection and prognosis evaluation. ［Methods］ The expression of p16 protein was analyzed by immunohistochemistry in gastric tissue array including normal gastric mucosa，paracancerous tissue，atypical hyperplasia tissue，gastric cancer tissue and metastatic lymph node.The relationship between expression of p16 and clinicopathologic features in gastric cancer were analyzed. ［Results］ The expression rate of p16 protein was 76.47% (26/34)，79.59% (39/49)，34.62% (9/26) and 8.64% (7/81) respectively in normal gastric mucosa tissue，paracancerous tissue，atypical hyperplasia tissue and gastric cancer tissue. The positive rate of p16 protein in gastric cancer tissue was lower than that in normal gastric mucosa tissue，paracancerous tissue and atypical hyperplasia tissue (P<0.01). The positive rate in atypical hyperplasia tissue was lower than that in normal gastric mucosa tissue and paracancerous tissue (P<0.05). The expression of p16 protein related to age，size of tumor and lymph node metastasis of gastric cancer(P<0.05). ［Conclusion］ The expression of p16 protein relates to cancer progress，age，size of tumor and lymph node metastasis of gastric cancer. |
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