| 孙国贵,胡万宁,张 钧.HIF-1α蛋白与食管鳞癌关系的荟萃分析[J].肿瘤学杂志,2012,18(9):686-691. |
| HIF-1α蛋白与食管鳞癌关系的荟萃分析 |
| A Meta-analysis of Relationship Between HIF-1α Expression and Esophageal Squamous Cell Carinoma |
| 投稿时间：2012-06-12 |
| DOI： |
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| 中文关键词: 食管肿瘤 鳞癌 乏氧诱导因子-1α Meta分析 |
| 英文关键词:esophageal neoplasms squamous cell carinoma HIF-1α Meta analysis |
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| 摘要点击次数: 1534 |
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| 中文摘要: |
| 摘 要: ［目的］ 探讨乏氧诱导因子-1α(HIF-1α)在食管鳞癌（ESCC）中的表达水平及与其临床病理特征之间的关系。［方法］ 检索Pubmed、EMBASE、Cochrane Library、中国期刊全文数据库、中国生物医学文献数据库、中文科技期刊全文数据库等，同时追查纳入文献的参考文献，纳入有关HIF-1α与ESCC关系的临床试验。采用Stata 11.0软件进行统计学分析。［结果］ 共纳入16篇文献，1 261例ESCC患者。Meta分析结果显示，HIF-1α在ESCC患者中的阳性表达水平明显增高（OR=33.11，95%CI：11.19~92.04）。临床病理结果显示，HIF-1α在ESCC低分化组与中高分化组的表达差异无统计学意义（P>0.05）。但HIF-1α表达在不同的T分期、淋巴结转移以及临床分期中差异均具有统计学意义（P＜0.05）。相关分析显示，HIF-1α与VEGF蛋白阳性率具有相关性。HIF-1α阳性表达者放化疗疗效显著低于HIF-1α阴性表达者（P＜0.05）。进一步生存分析显示，HIF-1α阳性表达的患者2年生存率明显低于阴性表达者（P＜0.05）。［结论］ HIF-1α在ESCC患者中高表达，增加了其恶性行为的发生危险，降低了ESCC患者放化疗疗效、2年生存率，同时HIF-1α与VEGF在ESCC中表达也有一定的相关性。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of Hypoxia-inducible factor-1α(HIF-1α) in patients with esophageal squamous cell carcinoma(ESCC) and its relationship with clinicopathological features. ［Methods］ Studies assessing clinical or prognostic significance of HIF-1α expression in patients with ESCC published until December 2011 were selected. A meta-analysis was performed to clarify the impact of HIF-1α expression on clinicopathological parameters，histologic response to chemotherapy or overall survival (OS) in ESCC. ［Results］ A total of 16 studies were recruited. The positive rate of HIF-1α expression was significantly different between ESCC group and control group (OR=33.11，95%CI:11.19~92.04). There was no significant difference between low differentiation group and high differentiation group(P＞0.05). However，there were significant differences between stage T3~T4 vs T1~T2，lymph node metastasis vs non-lymph node metastasis，stage Ⅲ-Ⅳ vsⅠ-Ⅱ，respectively (P＜0.05). HIF-1α expression positively correlated with vascular endothelial growth factor expression (P＜0.05) . The patients overexpressed HIF-1α had a worse response to chemoradiotherapy and a lower 2-year survival(P＜0.05). ［Conclusion］ HIF-1α might play an important role in the progress of ESCC，overexpression of HIF-1α correlates with not only the depth of invasion，lymph node metastasis and clinic stage but also the reduced response to chemoradiotherapy and OS. |
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