| 邓再兴,陈莉萍,赖世平.IMP3蛋白在乳腺癌中的表达及其临床意义[J].肿瘤学杂志,2012,18(9):670-673. |
| IMP3蛋白在乳腺癌中的表达及其临床意义 |
| Expression of IMP3 in Breast Cancer and Its Clinical Significance |
| 投稿时间：2012-04-06 |
| DOI： |
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| 中文关键词: 乳腺肿瘤 分子亚型 IMP3 免疫组织化学 |
| 英文关键词:breast neoplasmas molecular subtype IMP3 immunohistochemistry |
| 基金项目:浙江省医药卫生一般研究计划(2011KYA152)；湖州市自然科学资金项目(2011Y203) |
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| 中文摘要: |
| 摘 要：［目的］ 研究胰岛素样生长因子ⅡmRNA结合蛋白3（IMP3）在浸润性乳腺癌及其各分子亚型中的表达及其临床意义。［方法］收集189例浸润性乳腺癌组织标本，采用免疫组织化学法检测ER、PR和Her-2的表达情况，并据此将乳腺癌患者分为腺腔A型、腺腔B型、Her-2过表达型和基底细胞样型。用免疫组织化学法测定4种分子亚型乳腺癌组织中IMP3的表达情况，并分析IMP3表达与乳腺癌患者临床病理特征的关系。［结果］ 18.5%浸润性乳腺癌组织中有IMP3表达。IMP3的表达与组织学分级、Ki-67指数有关（P＜0.01），组织学分级越高及Ki-67指数高者IMP3表达越高。IMP3在腺腔A型、腺腔B型、Her-2过表达型和基底细胞样型中表达率分别为5.3%、10.0%、21.4%和58.3%。Her-2过表达型的IMP3表达率高于腺腔A型，差异有统计学意义（P＜0.05）。基底细胞样型表达率高于腺腔A型、腺腔B型及Her-2 过表达型，差异有统计学意义（P＜0.001）。IMP3阳性表达者生存率显著低于阴性表达者（P＜0.001）。［结论］ IMP3在基底细胞样型乳腺癌组织中高表达，其表达可作为乳腺癌预后的评估指标之一，并有可能成为基底细胞样型乳腺癌靶向治疗的一个新靶点。 |
| 英文摘要: |
| Abstract: ［Purpose］ To study the expression of insulin-like growth ⅡmRNA-binding protein 3(IMP3) in invasive breast cancer and in different molecular subtypes cancer and its clinical signifi-cance. ［Methods］ A total of 189 invasive breast cancer samples were collected. Expression of ER, PR and Her-2 were detected by immnohistochemical method, and the samples were categorized as follows: luminal A, luminal B, Her-2 over-expression and basal-like subtypes. The expression of IMP3 in all molecular subtypes was detected by immunohistochemical method, and the correlation of IMP3 expression with patients’ clinicopathological feature was analyzed.［Results］ The positive expression rate of IMP3 in invasive breast cancer was 18.5%. The expression of IMP3 correlated to histological grade and Ki-67 index, with significant difference (P＜0.01). The positive rates were higher in those patients with higher histological grade or higher Ki-67 index. The positive rates of IMP3 in luminal A,luminal B, Her-2 over-expression and basal-like subtypes were 5.3%, 10.0%, 21.4% and 58.3%, respectively. The positive rate of IMP3 in Her-2 over-expression subtype was remarkablely higher than that in luminal A subtype ,with significant difference(P＜0.05). The positive rate of IMP3 in basal-like subtype was remarkablely higher than those in luminal A, luminal B and Her-2 over-expression subtypes (P＜0. 001). The survival rate of patients with IMP3 positive-expression was significantly lower than that with negative-expression(P＜0.001). ［Conclusion］ IMP3 is highly expressed in basal-like subtype of breast cancer and may be a useful indicator for evaluating the prognosis of breast cancer, and it may be a new target for targeted therapy. |
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