| 陆筱灵,左 云,卢玮冬.紫杉醇脂质体联合奥沙利铂、氟尿嘧啶治疗晚期胃癌[J].肿瘤学杂志,2012,18(7):524-526. |
| 紫杉醇脂质体联合奥沙利铂、氟尿嘧啶治疗晚期胃癌 |
| Paclitaxel Liposome Combined with Oxaliplation and Fluorouacil Chemotherapy for Advanced Gastric Cancer |
| 投稿时间：2012-06-11 |
| DOI： |
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| 中文关键词: 胃肿瘤 紫杉醇脂质体 奥沙利铂 氟尿嘧啶 药物疗法 |
| 英文关键词:gastric neoplasms paclitaxel liposome oxaliplatin fluorouacil drug therapy |
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| 中文摘要: |
| 摘 要：［目的］ 观察紫杉醇脂质体联合奥沙利铂、氟尿嘧啶方案（POF）治疗晚期胃癌的临床疗效和不良反应。［方法］ 对48例晚期胃癌患者采用POF方案治疗，具体用法：紫杉醇脂质体135mg/m2，第1d静滴3h；奥沙利铂135mg/m2，第2d静滴2h；氟尿嘧啶500mg/m2，化疗泵内持续推注，d1~5。21d为1个周期，每2个周期评价疗效。［结果］ 48例患者均可评价疗效及毒性，其中完全缓解（CR）2例（4.2%），部分缓解（PR）23例（47.9%），稳定（SD）14例（29.2%），进展（PD）9例，总有效率（RR）52.1%，中位疾病进展时间（TTP）6.2个月，中位生存时间（MST）11.5个月。临床受益反应评价总有效率75.0%（36/48）。不良反应主要是骨髓抑制和消化道反应，Ⅲ～Ⅳ度骨髓抑制发生率为22.9%；其他外周神经毒性、肌肉酸痛、脱发，多为Ⅰ～Ⅱ度；无化疗相关性死亡病例。［结论］ 紫杉醇脂质体联合奥沙利铂、氟尿嘧啶（POF）治疗晚期胃癌的疗效确切，不良反应患者能够耐受，可以作为晚期胃癌的一线或二线治疗方案。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the clinical efficacy and toxicity of paclitaxel liposome combined with oxaliplatin and fluorouacil(POF) chemotherapy for advanced gastric cancer.［Methods］ Forty-eight cases with advanced gastric cancer were treated with POF regimen:pac-litaxel liposome 135mg/m2 iv 3h d1, oxaliplatin 135mg/m2 iv 2h d2, fluorouacil 500mg/m2 civ d1~5, 21d as a cycle. The treatment efficacy was evaluated after two cycles.［Results］ Forty-eight patients were evaluated. Complete response(CR) occurred in 2 cases (4.2%); partial response(PR),23 cases (47.9%); stable disease(SD), 14 cases (29.2%); and progression disease (PD), 9 cases, and overall response rate(RR), 52.1%. The median time to progression(TTP) was 6.2 months; and the median survival time(MST), 11.5 months. The clinical benefit response was 75.0%(36/48).The main toxicities were myelosuppression and digestive tract toxicity, including Ⅲ～Ⅳ degree myelosuppression (22.9％). Others toxicities included peripheral neurotoxicity, muscle aches and hair loss, mostly withⅠ~Ⅱ degree. No chemotherapy related death occurred. ［Conclusion］ Paclitaxel liposome combined with oxaliplatin and fluorouacil (POF) chemotherapy is effective and well tolerated as the first or second line regimen for patients with advanced gastric cancer. |
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