陈亚楠,左 云,宋 宇.进展期胃癌术后调强放疗序贯5-Fu微泵联合吡柔比星和奥沙利铂化疗[J].肿瘤学杂志,2012,18(5):336-338. |
进展期胃癌术后调强放疗序贯5-Fu微泵联合吡柔比星和奥沙利铂化疗 |
Clinical Study of Sequential Therapy of Intensity-modulated Radiotherapy and 5-Fu Minipump Combined with THP and LOHP Chemotherapy in the Treatment for Advanced Gastric Cancer Postoperation |
投稿时间:2012-02-03 |
DOI: |
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中文关键词: 调强放疗;5-Fu微泵 序贯化疗 胃肿瘤 |
英文关键词:intensity-modulated radiotherapy 5-Fu minipump sequential chemotherapy gastric neoplasms |
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中文摘要: |
摘 要:[目的] 观察进展期胃癌根治术后序贯放化疗的疗效及不良反应。[方法] 收集2008年7月~2010年7月进展期胃癌根治术后患者36例,随机分为序贯放化疗组(16例)和单纯化疗组(20例)。分析比较两组的1年生存率及1年无疾病进展生存率,同时评价治疗期间出现的血液学、胃肠道及肝肾功能等不良反应。[结果] 序贯放化疗组和单纯化疗组1年生存率分别为87.5%和65.0%,两组比较差异无统计学意义(P=0.099);1年无疾病进展生存率分别为75.0%和30.0%,差异有统计学意义(P=0.003)。主要不良反应有骨髓抑制、恶心、呕吐、脱发、纳差、腹泻及肝功能损害等,多以Ⅰ~Ⅱ度为主,Ⅲ~Ⅳ度发生率低,均可耐受。两组比较差异均无统计学意义(P>0.05)。[结论] 进展期胃癌术后调强放疗序贯5-Fu微泵联合吡柔比星和奥沙利铂化疗与单纯化疗相比,能提高术后1年无疾病进展生存率,急性不良反应轻,可耐受。 |
英文摘要: |
Abstract:[Purpose] To investigate the efficacy and side effects of sequential chemoradiotherapy in patients with advanced gastric cancer postoperation. [Methods] A total of 36 patients with advanced gastric cancer postoperation from July 2008 to July 2010 were randomly divided into 2 groups: sequential chemoradiotherapy group (16 cases) and chemotherapy alone group (20 cases). The 1-year survival rate and 1-year progress free survival rate were compared between the two groups. The side effects including hematological toxicity, gastrointestinal toxicity and liver and kidney toxicity were observed.[Results] The 1-year survival rates of sequential chemoradiotherapy group and chemotherapy alone group were 87.5% and 65.0% respectively, without significant difference(P=0.099). The 1-year progress free survival rates of sequential chemoradiotherapy group and chemotherapy alone group were 75.0% and 30.0% respectively, with significant difference(P=0.003).The major side effects were myelosuppression, nausea and vomiting, lipsotrichia, anorexia, diarrhea, liver function damage and so on. There was no significant difference between the two groups(P>0.05).[Conclusion] Compared with chemotherapy alone, sequential therapy of intensity-modulated radiotherapy and 5-Fu minipump combined with THP and LOHP chemotherapy in the treatment for advanced gastric cancer postoperation might improve the 1-year progress free survival,with mild side effects and tolerable. |
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