| 陈亚楠,左 云,宋 宇.进展期胃癌术后调强放疗序贯5-Fu微泵联合吡柔比星和奥沙利铂化疗[J].肿瘤学杂志,2012,18(5):336-338. |
| 进展期胃癌术后调强放疗序贯5-Fu微泵联合吡柔比星和奥沙利铂化疗 |
| Clinical Study of Sequential Therapy of Intensity-modulated Radiotherapy and 5-Fu Minipump Combined with THP and LOHP Chemotherapy in the Treatment for Advanced Gastric Cancer Postoperation |
| 投稿时间：2012-02-03 |
| DOI： |
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| 中文关键词: 调强放疗；5-Fu微泵 序贯化疗 胃肿瘤 |
| 英文关键词:intensity-modulated radiotherapy 5-Fu minipump sequential chemotherapy gastric neoplasms |
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| 中文摘要: |
| 摘 要：［目的］ 观察进展期胃癌根治术后序贯放化疗的疗效及不良反应。［方法］ 收集2008年7月~2010年7月进展期胃癌根治术后患者36例，随机分为序贯放化疗组（16例）和单纯化疗组（20例）。分析比较两组的1年生存率及1年无疾病进展生存率，同时评价治疗期间出现的血液学、胃肠道及肝肾功能等不良反应。［结果］ 序贯放化疗组和单纯化疗组1年生存率分别为87.5％和65.0％，两组比较差异无统计学意义（P＝0.099）；1年无疾病进展生存率分别为75.0％和30.0％，差异有统计学意义（P=0.003）。主要不良反应有骨髓抑制、恶心、呕吐、脱发、纳差、腹泻及肝功能损害等，多以Ⅰ～Ⅱ度为主，Ⅲ～Ⅳ度发生率低，均可耐受。两组比较差异均无统计学意义（P＞0.05）。［结论］ 进展期胃癌术后调强放疗序贯5-Fu微泵联合吡柔比星和奥沙利铂化疗与单纯化疗相比，能提高术后1年无疾病进展生存率，急性不良反应轻，可耐受。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the efficacy and side effects of sequential chemoradiotherapy in patients with advanced gastric cancer postoperation. ［Methods］ A total of 36 patients with advanced gastric cancer postoperation from July 2008 to July 2010 were randomly divided into 2 groups: sequential chemoradiotherapy group (16 cases) and chemotherapy alone group (20 cases). The 1-year survival rate and 1-year progress free survival rate were compared between the two groups. The side effects including hematological toxicity， gastrointestinal toxicity and liver and kidney toxicity were observed.［Results］ The 1-year survival rates of sequential chemoradiotherapy group and chemotherapy alone group were 87.5% and 65.0% respectively， without significant difference(P＝0.099). The 1-year progress free survival rates of sequential chemoradiotherapy group and chemotherapy alone group were 75.0% and 30.0% respectively， with significant difference（P=0.003）.The major side effects were myelosuppression， nausea and vomiting， lipsotrichia， anorexia， diarrhea， liver function damage and so on. There was no significant difference between the two groups（P＞0.05）.［Conclusion］ Compared with chemotherapy alone， sequential therapy of intensity-modulated radiotherapy and 5-Fu minipump combined with THP and LOHP chemotherapy in the treatment for advanced gastric cancer postoperation might improve the 1-year progress free survival，with mild side effects and tolerable. |
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