| 戴 群,卢 峰,梁万霞.适形放疗加同步化疗治疗局部晚期胃癌的疗效观察[J].肿瘤学杂志,2012,18(4):259-262. |
| 适形放疗加同步化疗治疗局部晚期胃癌的疗效观察 |
| Effect of Concurrent Conformal Radiotherapy and Chemotherapy for Locally Advanced Gastric Cancer |
| 投稿时间：2012-01-30 |
| DOI： |
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| 中文关键词: 胃肿瘤 同步放化疗 三维适形放疗 |
| 英文关键词:stomach neoplasms concurrent chemoradiotherapy three dimensional conformal radiotherapy |
| 基金项目: |
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| 摘要点击次数: 1634 |
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| 中文摘要: |
| 摘 要： ［目的］观察适形放疗加同步化疗治疗局部晚期胃癌的近期疗效及不良反应。［方法］36例局部晚期胃癌患者分为治疗组和对照组，治疗组17例给予FOLFOX4方案化疗并同步三维适形放疗（总剂量45~50 Gy）；对照组19例仅给予化疗，方案同治疗组。［结果］ 36例患者全部完成治疗，治疗组、对照组有效（RR）率为76.5%、42.1%，疾病控制（DCR）率为88.2%、57.9%，两组间RR率、DCR率比较差异均有统计学意义（P<0.05）；两组不良反应如消化道反应、骨髓抑制、外周神经毒性等方面，差异均无统计学意义（P>0.05）。［结论］ 适形放疗加同步化疗治疗局部晚期胃癌疗效确切，不良反应可以耐受，值得进一步研究。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the short-term response and toxicity of concurrent conformal radiotherapy and chemotherapy for locally advanced gastric cancer. ［Methods］ Thirty-six cases with locally advanced gastric cancer were divided into treatment group and control group.The treatment group (17 cases ) received FOLFOX4 regimen chemotherapy and concurrent three-dimensional conformal radiotherapy (total doses 45~50 Gy)，and the control group (19 cases)，with the same regimen chemothera-py alone as the treatment group.［Results］ All the 36 patients completed the treatment，with short-term response rate(RR) 76.5% and 42.1%，disease control rate (DCR) 88.2% and 57.9% in the treatment group and control group respectively. There was significant difference in RR or DCR between the two groups(P<0.05). There was no significant difference between the two groups in the digestive tract toxicity，myelosuppression，peripheral neuritis(P>0.05). ［Conclusion］ Concurrent conformal radiotherapy and chemotherapy for locally advanced gastric cancer is effective，and its toxicities are tolerable. |
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