| 罗祖炎,李 博,徐文娟.IGF-1在胃癌组织中的表达及其与浸润转移的关系[J].肿瘤学杂志,2012,18(4):254-258. |
| IGF-1在胃癌组织中的表达及其与浸润转移的关系 |
| Expression of IGF-1 in Gastric Cancer and Its Relationship with Cancer Invasion and Metastasis |
| 投稿时间：2012-01-11 |
| DOI：10.11735/j.issn.1671-170X.2012.4.B2012018 |
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| 中文关键词: 胃肿瘤 肿瘤浸润 肿瘤转移 胰岛素样生长因子-1 |
| 英文关键词:gastric neoplasms neoplasm invasion neoplasm metastasis insulin-like growth factor-1 |
| 基金项目:国家卫生公益性行业专项经费资助(200802112) |
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| 摘要点击次数: 2099 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胃癌中IGF-1蛋白的表达及其与肿瘤浸润转移的关系。［方法］ 免疫组织化学技术分析436例胃癌组织及92例邻近正常胃黏膜组织石蜡标本中IGF-1的表达。 ［结果］ IGF-1在正常胃黏膜组织的表达低于胃癌组织（0 vs 49.5%，χ2=77.132，P<0.001）； IGF-1表达与胃癌患者肿瘤大小、分化、侵犯深度、分期、淋巴结转移、远处转移、脉管侵犯、Lauren分型相关，而与组织学类型、性别无关。胃癌患者中肿瘤大小≥5cm患者的IGF-1阳性表达率为64.4%，明显高于<5cm的患者（39.1%，χ2=27.238，P<0.001）；弥漫型胃癌患者IGF-1的阳性表达率明显高于肠型患者（85.0% vs 15.7%，χ2=209.184，P<0.001）;T3、T4期胃癌患者的IGF-1阳性表达率分别为62.7%、92.3%，明显高于T1、T2期的10.5%、30.3%（χ2=86.830，P<0.001）;脉管侵犯患者的IGF-1阳性表达率明显高于无脉管侵犯者（71.5% vs 19.1%，χ2=116.710，P<0.001）；淋巴结转移患者的IGF-1阳性表达率为70.0%，明显高于无淋巴结转移者（16.3%，χ2=118.740，P<0.001）；远处转移患者的IGF-1阳性表达率为95.1%，明显高于无远处转移者（42.1%，χ2=58.841，P<0.001）。［结论］ IGF-1与胃癌的发生发展有关，参与胃癌的浸润转移进程。检测IGF-1的表达可作为判断胃癌生物学行为的重要参考指标。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of IGF-1 and its relationship with invasion and metastasis in gastric cancer. ［Methods］ IGF-1 expression in sample tissues of 436 cases with gastric cancer and 92 cases of cancer adjacent gastric mucosa was detected immunohistochemically. ［Results］ IGF-1 expression in cancer adjacent gastric mucosa was significantly lower than that in gastric cancer tissues (0 vs 49.5%，χ2= 77.132，P<0.001).IGF-1 expression was related to tumor size，differentiation，depth of invasion，stage，lymph node metastasis，distant metastasis，vascular invasion，Lauren classification of gastric cancer，except the histologic type and gender. IGF-1 positive expression rate in gastric cancer patients with tumor size≥5cm (64.4%) increased significantly than that in patients with tumor size <5cm (39.1%，χ2= 27.238，P<0.001). IGF-1 positive expression rate in patients with diffusing type cancer(85.0%) increased significantly than that in intestinal-type cancer(15.7%，χ2=209.184，P<0.001）. IGF-1 positive expression rate in patients stage T3 and T4(62.7% and 92.3%) increased significantly than that in T1 and T2 stage patients(10.5% and 30.3%，χ2=86.830，P<0.001）. IGF-1 positive expression rate in patients with vascular invasion (71.5%) increased significantly than that in patients without vascular invasion（19.1%，χ2=116.710，P<0.001）. IGF-1 positive expression rate in patients with lymph node metastasis (70.0%)increased significantly than that in patients without lymph node metastasis（16.3%，χ2=118.740，P<0.001）. IGF-1 positive expression rate in patients with distant metastasis (95.1%) increased significantly than that in patients without distant metastasis（42.1%，χ2=58.841，P<0.001）.［Conclusion］ IGF-1 relates to the carcinogenesis of gastric cancer，and involves in the process of invasion and metastasis of gastric cancer. IGF-1 expression could be used as an important reference indicator for biological behavior for gastric cancer. |
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