| 张艳艳,范雪娇,余红平.p53 codon72单核苷酸多态性与肝细胞癌发病风险的关系[J].肿瘤学杂志,2012,18(3):189-193. |
| p53 codon72单核苷酸多态性与肝细胞癌发病风险的关系 |
| Association of p53 Codon72 Polymorphism and Risk of Hepatocellular Carcinoma |
| 投稿时间：2012-01-03 |
| DOI：10.11735/j.issn.1671-170X.2012.3.B2012002 |
|
 |
| 中文关键词: p53基因 单核苷酸多态性 肝细胞癌 发病风险 |
| 英文关键词:p53 gene single nucleotide polymorphism hepatocellular carcinoma incidence risk |
| 基金项目:广西科学研究与技术开发项目（0719006-2-13） |
|
| 摘要点击次数: 3021 |
| 全文下载次数: 1531 |
| 中文摘要: |
| 摘 要：［目的］ 探讨广西地区p53基因codon72单核苷酸多态性(SNP)与肝细胞癌(HCC)发病风险的关系。［方法］ 采用TaqMan MGB探针等位基因分型技术对985例肝癌病例和相匹配的992例非肿瘤对照的p53 codon72(Arg>Pro，rs1042522)基因型进行检测，并分析该SNP与肝癌发病风险的关系。［结果］ p53 codon72多态性与肝癌发病风险之间无统计学关联(Arg/Pro: 校正OR=1.15，95%CI: 0.83~1.59; Pro/Pro: 校正OR=1.16，95%CI: 0.80~1.68; Arg/Pro+Pro/Pro: 校正OR=1.15，95%CI：0.85~1.57)。按是否吸烟、饮酒、HBV和HCV感染分层分析，亦未发现p53 codon72多态性与肝癌发病风险有关。但基因—环境交互作用显示，该基因多态性与吸烟、饮酒和HBV感染存在交互作用，OR值分别为2.42(95%CI：1.47~3.97)、2.96(95%CI：1.82~4.80)和62.74(95%CI：34.39~114.46)。［结论］ p53 codon72的单独效应可能与肝癌易感性无关联，但该SNP与吸烟、饮酒和HBV感染存在基因—环境交互作用，增加肝癌的发病风险。 |
| 英文摘要: |
| Abstract：［Purpose］ To explore associations between p53 single nucleotide polymorphism (SNP) codon72 and risk of hepatocellular carcinoma (HCC) in Guangxi. ［Methods］ A hospital-based case-control study was conducted in 985 cases with HCC and 992 cancer-free matched controls. p53 codon72 genotypes (Arg>Pro，rs1042522) were detected by Applied Biosystems TaqMan genotyping platform. ［Results］ The variant genotypes of p53 codon72 did not significantly associate with risk of HCC (Arg/Pro：adjusted OR=1.15，95%CI：0.83~1.59; Pro/Pro：adjusted OR=1.16，95%CI：0.80~1.68; Arg/Pro+Pro/Pro: adjusted OR=1.15，95%CI：0.85~1.57). After stratified with smoking，alcohol drinking，HBV and HCV infections，no risk increasing genotype was found. However，interactions between p53 codon72 polymorphism and smoking，alcohol drinking and HBV infection might modify the risk of HCC ［smoking (adjusted OR=2.42，95%CI：1.47~3.97)，alcohol drinking (adjusted OR=2.96，95%CI：1.82~4.80) and HBV infection (adjusted OR=62.74，95%CI：34.39~114.46)］. ［Conclusion］ p53 codon72 may not have the independent effect on the susceptibility to HCC. However，the interactions between p53 codon72 polymorphism and smoking，alcohol drinking and HBV infection might modify the risk of HCC. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |