| 姚 娓,刘艳红,张 红.蜂房提取物抑制H22小鼠移植瘤增殖的作用研究[J].肿瘤学杂志,2012,18(4):270-273. |
| 蜂房提取物抑制H22小鼠移植瘤增殖的作用研究 |
| Study of the Inhibitory Effect of Nidus Vespae Extracts on Proliferation of H22 Transplanted Tumor in Mice |
| 投稿时间：2011-10-27 |
| DOI： |
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| 中文关键词: 蜂房提取物 H22肝癌 C-Met 抑瘤作用 |
| 英文关键词:nidus vespae extracts H22 hepatoma C-Met antitumor effect |
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| 摘要点击次数: 1732 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨蜂房提取物对小鼠H22肿瘤细胞生长的影响及其抑瘤作用机制。［方法］将40 只小鼠随机分为盐水对照组、氟尿嘧啶组、蜂房高剂量组和蜂房低剂量组，每组10只。测定荷瘤小鼠的瘤质量和抑瘤率，观察蜂房提取物对肿瘤生长的影响，同时采用免疫组化方法检测瘤组织中C-Met的表达。［结果］ 蜂房高、低剂量组的抑瘤率分别为31.96%、27.84%，与盐水对照组比较差异有统计学意义(P<0.01)；C-Met在4组中均呈阳性表达，与盐水对照组比较，蜂房高、低剂量组C-Met的表达减弱，差异有统计学意义（P<0.05）。［结论］ 蜂房提取物对小鼠H22移植性实体瘤有明显的抑制作用，其机制可能与降低肝癌细胞内C-Met的表达有关。 |
| 英文摘要: |
| Abstract: ［Purpose］ To explore the antitumor effect of nidus vespae extracts on H22 transplanted tumor cell in mice and its mechanism. ［Methods］ Forty mice were randomly divided into 4 groups: saline control group，5-Fu group，high-dose nidus vespae group and low-dose nidus vespae group. The tumor weights and rates of tumor inhibition were compared among the groups. Then the expression of C-Met was detected by immunohistochemistry. ［Results］ The rates of tumor inhibition in high-dose nidus vespae group and low-dose nidus vespae group were 31.96% and 27.84% respectively，with significant difference compared to saline control group (P<0.01). The expression of C-Met decreased in both the high-dose nidus vespae group and low-dose nidus vespae group，and there was apparent difference with that in saline control group（P<0.05）. ［Conclusion］ The inhibitory effects of nidus vespae extracts on H22 transplanted tumor cells are significant and the mechanism may be related to reducing expression of C-Met. |
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