| 嵇学仙,陈秋强,石麒麟.非小细胞肺癌MMP-3和TIMP-3表达与间质微血管密度和肿瘤转移的关系[J].肿瘤学杂志,2012,18(3):185-188. |
| 非小细胞肺癌MMP-3和TIMP-3表达与间质微血管密度和肿瘤转移的关系 |
| Expressions of MMP-3 and TIMP-3 and Their Correlation with Tumor Interstitial Microvascular Density and Cancer Metastasis in Non-small Cell Lung Cancer |
| 投稿时间：2011-08-23 |
| DOI： |
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| 中文关键词: 非小细胞肺癌 基质金属蛋白酶-3 基质金属蛋白酶抑制剂-3 微血管密度 免疫组织化学 |
| 英文关键词:non-small cell lung cancer MMP-3 TIMP-3 microvascular density immunohistochemistry |
| 基金项目:浙江省湖州市科技计划项目（2007YS36） |
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| 中文摘要: |
| 摘 要：［目的］ 研究基质金属蛋白酶-3(MMP-3)及其抑制物组织基质金属蛋白酶抑制剂-3(TIMP-3)在非小细胞肺癌组织中的表达特点，探讨其与间质微血管密度（MVD）及肿瘤转移的关系。［方法］ 通过免疫组化的方法检测97例NSCLC原发灶及其淋巴结转移灶中MMP-3和TIMP-3的表达，并在CD34染色切片上检测MVD。［结果］ MMP-3在NSCLC淋巴结转移灶中的阳性率(74.1%)显著高于原发灶中的阳性率(56.7%)（P<0.05)，而TIMP-3在转移灶中的阳性率(37.0%)显著低于原发灶中的阳性率(64.9%)（P<0.05)。MMP-3和TIMP-3在NSCLC原发及转移灶中表达均具有相关性(P<0.05)。 NSCLC中MMP-3表达阳性者MVD高于MMP-3表达阴性者（P=0.013）。TIMP-3表达阳性者MVD低于TIMP-3表达阴性者（P=0.035）。［结论］ MMP-3和TIMP-3参与NSCLC的发生发展过程。MMP-3、TIMP-3的表达和MVD可能与NSCLC的生物学特性相关，对判断预后和指导治疗具有实用价值。 |
| 英文摘要: |
| Abstract: ［Purpose］ To study the expressions of MMP-3 and TIMP-3 and their correlation with interstitial microvascular density(MVD) and cancer metastasis in non-small cell lung cancer（NSCLC）. ［Methods］ Immunohistological staining was used to detect the expressions of MMP-3，TIMP-3 and MVD in 97 cases with NSCLC and their metastatic lesions. ［Results］ The positive rates of MMP-3 were 56.7% and 74.1% in primary and metastatic lesions respectively，with signifi-cant difference (P<0.05). The positive rates of TIMP-3 were 64.9% and 37.0% respectively，also with significant difference (P<0.05). The expression of MMP-3 and TIMP-3 was correlated both in primary and metastatic lesions of NSCLC（P<0.05）. MVD was significantly higher in cases with MMP-3 positive expression than that in cases with MMP-3 negative expression (P=0.013). MVD was lower in cases with TIMP-3 positive expression than that in cases with TIMP-3 negative expression (P=0.035). ［Conclusions］ MMP-3 and TIMP-3 might take part in the carcinogensis and progress of NSCLC. The expressions of MMP-3，TIMP-3 and MVD might be related to the biological characteristics of NSCLC and have the practical value in prognosis and treatment of NSCLC. |
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