| Abstract: [Purpose] To analyze the epidemiological characteristics and trends in laryngeal cancer incidence and mortality in Zhejiang cancer registration areas from 2000 to 2021, and to provide a basis for developing prevention and control strategies. [Methods] Data on laryngeal cancer incidence and mortality reported by Zhejiang cancer registries areas from 2000 to 2021 were collected, reviewed by the Zhejiang Cancer Center. The crude incidence/mortality rates, age-standardized incidence/mortality rates by Chinese populations (ASIRC/ASMRC) and world standard populations (ASIRW/ASRW), cumulative rates, and truncated rates were calculated. Joinpoint regression models was used to estimate the average annual percentage change (AAPC) to assess trends. [Results] From 2000 to 2021, the average crude incidence rate of laryngeal cancer in Zhejiang cancer registration areas was 1.97/105, the ASIRC rate was 1.09/105, and the ASIRW was 1.12 /105; The 0~74 years older cumulative incidence rate was 0.14%, and the 35~64 years older truncated incidence rate was 1.95/105; The crude mortality rate for laryngeal cancer was 0.74/105, with the ASMRC rates of 0.38/105 and the ASRW 0.38/105. The 0~74 years cumulative mortality rate was 0.04%, and the 35~64 years truncated mortality rate was 0.44/105. The incidence of laryngeal cancer remains at a relatively low level before age 40 and rises rapidly after age 50. Overall incidence and incidence among men peak in the 75~79 age group, while incidence among women peaks in the 80~84 age group. From 2000 to 2021, the ASIRC of laryngeal cancer remained generally stable. The ASIRC among women showed a significant downward trend (AAPC =-4.66%, 95% CI: -6.79%~2.30%, P < 0.001), whereas in rural areas, it showed a significant upward trend (AAPC = 4.48%, 95% CI: 2.50%~6.56%, P <0.001). The ASMRC for laryngeal cancer showed an upward trend (AAPC = 3.16%, 95% CI: 0.19%~5.40%, P <0.05), with ASMRC among men also showing a significant increase (AAPC = 2.20%, 95% CI: 0.28%~4.24%, P <0.05); the AAPC for female patients was 31.32% (95% CI: 8.40%~46.82%, P <0.05). [Conclusion] From 2000 to 2021, the incidence and mortality rates of laryngeal cancer in Zhejiang Province remained generally low overall; however, the ASMRC showed an upward trend, with men and individuals aged 75 and older constituting the core groups at highest risk of death. Efforts should focus on middle-aged and elderly rural men, and comprehensive prevention and control measures, including tobacco and alcohol control, occupational protection, and early screening, should be strengthened to reduce the burden of laryngeal cancer. |
