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2021年浙江省肿瘤登记地区骨恶性肿瘤发病、死亡现状及2000-2021年变化趋势

Incidence and Mortality of Malignant Bone Tumors in Zhejiang Cancer Registration Areas in 2021 and Trends from 2000 to 2021

投稿时间：2026-06-12 修订日期：2026-08-17

DOI：

中文关键词: 骨恶性肿瘤发病率死亡率浙江

英文关键词:malignant bone tumors incidence mortality Zhejiang

基金项目:浙江省疾病预防控制科技计划项目

作者	单位	邮编
彭二磊	湖州市南浔区疾病预防控制中心（南浔区卫生监督所）	313009
沈红伟	湖州市南浔区疾病预防控制中心（南浔区卫生监督所）	313009
张一璐	湖州市南浔区疾病预防控制中心（南浔区卫生监督所）	313009
杨丽萍	湖州市南浔区疾病预防控制中心（南浔区卫生监督所）	313009
杜灵彬	浙江省肿瘤医院	310022
李辉章^*	浙江省肿瘤医院	310022

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中文摘要:

摘要：[目的] 分析2021年浙江省肿瘤登记地区骨恶性肿瘤发病和死亡现状以及2000—2021年变化趋势。[方法] 收集并整理浙江省22个肿瘤登记处上报的2000—2021年骨恶性肿瘤发病和死亡数据，计算骨恶性肿瘤发病和死亡粗率、中标发病率(age-standardized incidence rate by Chinese standard population，ASIRC)和中标死亡率(age-standardized mortality rate by Chinese standard population，ASMRC)、0~74岁累计率以及35~64岁截缩率等指标。采用Joinpoint回归模型计算骨恶性肿瘤标化发病率和死亡率的平均年度变化百分比（average annual percentage change，AAPC）及95%置信区间（confidence interval, CI），并分析变化趋势。[结果] 2021年浙江省肿瘤登记地区骨恶性肿瘤的粗发病率为1.13/10万，ASIRC为0.80/10万，粗死亡率为 0.65/10万，ASMRC为0.37/10万；男性的ASIRC（0.93/10万）和ASMRC（0.45/10万）均高于女性（0.69/10万、0.28/10万）；城市地区ASIRC（0.75/10万）略低于农村地区（0.88/10万），ASMRC（0.38/10万）略高于农村地区（0.35/10万）。骨恶性肿瘤的粗发病率和粗死亡率总体随年龄增长呈上升趋势，60岁以后快速上升，80岁以后达到高峰。2000—2021年浙江省肿瘤登记地区骨恶性肿瘤总体ASIRC和ASMRC均呈明显下降趋势（ASIRC：AAPC=-6.45，95%CI: -7.68~-5.11，P＜0.001；ASMRC：AAPC=-5.08，95%CI: -6.29~-3.81，P＜0.001），其中男性、女性、城市地区的ASIRC与ASMRC均呈下降趋势，农村地区ASIRC变化无统计学显著性。[结论] 浙江省骨恶性肿瘤负担总体呈持续下降趋势，城乡间的发病和死亡差异不显著。

英文摘要:

Abstract: [Purpose] To analyze the incidence and mortality of malignant bone tumors in Zhejiang cancer registration areas in 2021 and the trend from 2000 to 2021. [Methods] The incidence and mortality data of malignant bone tumors from 2000 to 2021 reported by 22 cancer registries in Zhejiang were collected and sorted. Indicators including crude incidence rate, crude mortality rate, age-standardized incidence rate by Chinese standard population (ASIRC), age-standardized mortality rate by Chinese standard population (ASMRC), cumulative rate (0~74 years old), and truncated rate (35~64 years old) were calculated. The Joinpoint regression model was used to estimate the average annual percentage change (AAPC) together with its 95% confidence interval (CI) of ASIRC and ASMRC, and to analyze the long-term trends. [Results] In 2021, the crude incidence rate of malignant bone tumors in Zhejiang cancer registration areas was 1.13/10? and the ASIRC was 0.80/10?; the crude mortality rate was 0.65/10? and the ASMRC was 0.37/10?. Both ASIRC (0.93/10?) and ASMRC (0.45/10?) in males were higher than those in females (0.69/10? and 0.28/10?, respectively). The urban ASIRC (0.75/10?) was slightly lower than the rural counterpart (0.88/10?), while the urban ASMRC (0.38/10?) was slightly higher than the rural ASMRC (0.35/10?). The crude incidence and mortality rates generally increased with age, rising rapidly after the age of 60 and peaking after 80 years old. From 2000 to 2021, the overall ASIRC and ASMRC of malignant bone tumors in cancer registration areas of Zhejiang Province presented a notable downward trend (ASIRC: AAPC= -6.45, 95%CI:-7.68~-5.11, P<0.001; ASMRC: AAPC=-5.08, 95%CI:-6.29~-3.81, P<0.001). Stratified analysis showed declining trends in ASIRC and ASMRC among males, females and urban populations, while the temporal variation of ASIRC in rural areas was not statistically significant. [Conclusion] The overall disease burden of malignant bone tumors in Zhejiang Province keeps decreasing continuously, and no significant disparities in incidence and mortality are observed between urban and rural areas.

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