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| 小细胞肺癌精准诊疗：从分子通路到临床实践 |
| Precision Diagnosis and Treatment of Small Cell Lung Cancer: From Molecular Pathways to Clinical Practice |
| 投稿时间：2026-06-11 修订日期：2026-09-06 |
| DOI： |
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| 中文关键词: 小细胞肺癌 视网膜母细胞瘤蛋白1 P16蛋白 细胞周期蛋白D1 分子分型 精准治疗 |
| 英文关键词:Small cell lung cancer Retinoblastoma protein 1 P16 protein Cyclin D1 Molecular classification Precision therapy |
| 基金项目:国家自然科学基金地区项目（No.82360523）；云南省联合专项重点项目（No.202001AY070001‑007）；兴滇人才计划“名医专项”（No.RLMY20220018）；昆明医科大学肺部恶性肿瘤精准病理诊断科技创新团队（No.CXTD202210）；校级一流学科特色团队（No.2024XKTDTS11）；云南省神经心脏系统疾病临床医学中心（No.YWLCYXZX2023300077）；医学中心科研项目（No.2024YNLCYXZX0050） |
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| 中文摘要: |
| 小细胞肺癌是高侵袭性肺部神经内分泌肿瘤，远期生存率低，传统诊疗模式难以突破现有瓶颈。细胞周期调控紊乱深刻影响肿瘤进展与耐药进程，基于视网膜母细胞瘤蛋白1/P16/细胞周期蛋白D1通路可实现疾病精准分型。本文系统阐述该通路的作用机制与亚型分化特点，归纳相关标志物在临床诊断、预后判断及个体化治疗中的实践价值。近年来，空间组学技术逐步解析肿瘤空间架构、细胞互作与瘤内异质性，成为该领域新兴研究热点。文章同时剖析检测标准不统一、耐药机制不明等现实问题，并结合空间生物学前沿成果展望发展趋势，为推进小细胞肺癌规范化、精准化诊疗提供思路。 |
| 英文摘要: |
| Small cell lung cancer is a highly aggressive pulmonary neuroendocrine tumor with low long-term survival rate, and traditional diagnosis and treatment modes can hardly break through current bottlenecks. Disorders of cell cycle regulation profoundly affect tumor progression and drug resistance, and precise classification can be realized based on the retinoblastoma protein 1/P16/cyclin D1 pathway. This article elaborates on the functional mechanism and subtype differentiation characteristics of the pathway, and summarizes the practical value of relevant markers in clinical diagnosis, prognostic judgment and individualized treatment. In recent years, spatial omics technologies have gradually resolved tumor spatial architecture, cellular interaction and intratumoral heterogeneity, becoming a new research hotspot. This paper also analyzes practical problems such as inconsistent detection criteria and unclear drug resistance mechanisms, and prospects development trends combined with cutting-edge achievements in spatial biology, providing ideas for standardized and precise diagnosis and treatment of small cell lung cancer. |
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