| Cuproptosis is a newly identified form of regulated cell death that has attracted attention in recent years. It is triggered by copper overload, which disrupts mitochondrial function, enhances oxidative stress, and disturbs the tricarboxylic acid cycle, ultimately leading to cytotoxicity. Growing evidence suggests that dysregulation of cuproptosis is closely linked to the initiation and progression of various tumors. Long non-coding RNAs (lncRNAs) are a class of RNA molecules longer than 200 nucleotides that lack protein-coding potential. They have emerged as important regulators in tumorigenesis, metastasis, and drug resistance. With deeper investigation, the roles of cuproptosis-related lncRNAs in gastric cancer(GC)and their potential clinical applications have become a new focus of research. Accumulating data indicate that specific lncRNAs can modulate the expression of key cuproptosis genes either directly or indirectly, often through competing endogenous RNA (ceRNA) networks, thereby affecting the proliferation, invasion, and metastatic ability of GC cells. In this review, we summarize the core molecular mechanisms of cuproptosis and the regulatory functions of cuproptosis-associated lncRNAs in GC. We place particular emphasis on their implications for prognosis evaluation, tumor microenvironment remodeling, and therapeutic sensitivity. By integrating these findings, we aim to provide novel theoretical insights and research directions for precision diagnosis, prognostic monitoring, and immunotherapy in GC. |
