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| 脂肪酸β氧化在肝细胞肝癌中的双重作用与调控机制研究现状及进展 |
| Dual Roles and Underlying Regulatory Mechanisms of Fatty Acid β Oxidation in HCC: Current Status and Recent Advances |
| 投稿时间：2025-12-22 修订日期：2026-04-15 |
| DOI： |
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| 中文关键词: 肝细胞肝癌 脂肪酸代谢 能量代谢重编程 |
| 英文关键词:Hepatocellular carcinoma (HCC) Fatty acid metabolism Energy metabolic reprogramming |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）；北京市自然科学基金昌平重点项目 |
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| 中文摘要: |
| 肝癌是全球范围内极具危害性的恶性肿瘤之一，肝细胞肝癌 (Hepatocellular Carcinoma, HCC) 作为原发性肝癌的主要亚型，占比达80%。在多种致癌因素作用下，正常肝组织可发生恶性转化，但 HCC 发病的分子机制尚未完全明确，细胞代谢重编程是癌症的重要特征，其中脂肪酸代谢尤其是β氧化在 HCC 能量代谢重编程中的作用日益凸显。本文综述了β氧化在 HCC 中的作用，包括其在能量代谢中的双重功能，以及相关基因、信号通路对β氧化的调控机制等研究进展，旨在为深入理解 HCC 代谢重编程机制及开发新的治疗策略提供依据。 |
| 英文摘要: |
| Hepatocellular carcinoma (HCC), accounting for 80% of primary liver cancers, is one of the most devastating malignant tumors worldwide. Under the influence of multiple carcinogenic factors, normal liver tissue can undergo malignant transformation; however, the molecular mechanisms underlying HCC initiation and progression remain incompletely elucidated. Metabolic reprogramming is a key hallmark of cancer, and the role of fatty acid metabolism, particularly β-oxidation, in the reprogramming of energy metabolism in HCC has become increasingly prominent. This review summarizes the current research progress on the roles of β-oxidation in HCC, including its dual functions in energy metabolism and the regulatory mechanisms of related genes and signaling pathways on β-oxidation. The aim is to provide a basis for a deeper understanding of the metabolic reprogramming mechanisms in HCC and the development of novel therapeutic strategies. |
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