| Cordyceps militaris is a fungus with both medicinal and edible uses, whose active components primarily include cordycepin, cordyceps polysaccharides, ergosterol, and selenium. In recent years, the active substances of Cordyceps militaris have garnered significant attention for their diverse effects, including antioxidant, anti-inflammatory, antitumor, and immunomodulatory properties.Currently, extensive research has focused on its bioactive components, pharmacological effects, and industrial applications, but there are few review articles on its molecular mechanisms for antitumor activity remain scarce. Based on this, this paper systematically reviews the latest advances in the molecular mechanisms of Cordyceps militaris' active components against tumors. It compares the differences in the effects of cordycepin and Cordyceps polysaccharides on cell cycle arrest, apoptosis, autophagy, immune modulation, and drug resistance reversal, and summarizes the latest strategies for enhancing cordycepin bioavailability.This not only provides a theoretical foundation for in-depth research on natural products but also offers new insights for their development and application in cancer treatment. |
