妇科恶性肿瘤相关血小板增多症研究进展
Research Progress on Thrombocytosis Associated with Gynecological Malignancies
投稿时间:2025-08-10  修订日期:2025-12-04
DOI:
中文关键词:  血小板增多症  妇科恶性肿瘤  血栓
英文关键词:Thrombocytosis  Gynecological Malignancies  thrombus
基金项目:
作者单位邮编
田东立 中国医科大学附属第一医院 110001
李芳梅 中国医科大学附属第一医院 
张师前 山东大学齐鲁医院 
张 颐* 中国医科大学附属第一医院 110001
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中文摘要:
      血小板在组织重塑、伤口愈合和血管完整性维持等生理过程中具有重要的作用。血小板也与恶性肿瘤的发生发展相关,肿瘤相关的炎症因子可诱导血小板数量异常升高,不仅助力肿瘤新生血管的生成,还能增强肿瘤的侵袭性和转移。血小板增多会抑制机体抗肿瘤免疫反应,促进肿瘤细胞对化疗产生耐药性,从而加速病情恶化。血小板增多症常提示更高的肿瘤负荷和较差的生存预后,可能成为评估妇科肿瘤患者预后的重要标志,针对血小板的治疗或可作为妇科恶性肿瘤潜在的辅助治疗手段,亟需进一步的科学研究和临床试验以验证其有效性。
英文摘要:
      Platelets play a crucial role in physiological processes such as tissue remodeling, wound healing, and maintaining vascular integrity. Platelets are also associated with the occurrence and development of malignant tumors. Tumor-related inflammatory factors can induce abnormal elevation of platelet counts, which not only facilitate the formation of new blood vessels in tumors but also enhance the invasiveness and metastasis of tumors. Elevated platelet counts can suppress the body"s anti-tumor immune response and promote tumor cell resistance to chemotherapy, thereby accelerating disease progression. Thrombocytosis often indicates a higher tumor burden and a poorer prognosis, and may become an important marker for evaluating the prognosis of gynecological tumor patients. Targeting platelets as a potential adjuvant treatment for gynecological malignancies is an urgent need for further scientific research and clinical trials to verify its effectiveness.
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