| [Purpose] To analyze the trends in the mortality of malignant tumors，change of the mortality spectrum among residents in Yangpu District, Shanghai, from 2010 to 2021, and to explore its impact o on life expectancy.[Methods] Based on the mortality surveillance data of registered residents in Yangpu District from 2010 to 2021, the crude mortality rate, standardized mortality rate, life expectancy, and cause-eliminated life expectancy (CELE) of malignant tumors, as well as the average annual percentage change (AAPC) of these indicators were calculated. [Results] From 2010 to 2021, a total of 35,122 people in Yangpu District died of malignant tumors, including 21,258 males (60.53%). The CMR of malignant tumors in the entire population increased from 242.99/105 in 2010 to 291.80/105 in 2021 (AAPC = 1.77%, P < 0.05), while the standardized mortality rate decreased from 185.46/105 to 152.80/105 (AAPC = ?1.68%, P < 0.05). Both the crude and standardized mortality rates increased in males and females, but the standardized mortality rates decreased in both genders, with males consistently having higher mortality rates than females. The CMR of in the entire population and in both genders increased with age. Life expectancy showed an upward trend (AAPC = 0.24%, P = 0.001), increasing by 1.98 years in 2021 compared with 2010. The CELE of malignant tumors also increased (AAPC = 0.23%, P =0.001), while the trends in PGLEs and years of life lost were not statistically significant (P > 0.05). There were significant changes in the mortality spectrum of malignant tumors. The mortality burden of urinary system tumors (prostate cancer and bladder cancer) and some digestive tract tumors (colon cancer, rectal cancer, and pancreatic cancer) increased. In contrast, the mortality burden of liver cancer and brain malignancies decreased. Lung cancer remained the leading cause of death in the population, with a continuously increasing mortality rate. [Conclusion] The mortality rate of malignant tumors in Yangpu District increased from 2010 to 2021. The mortality rate, mortality spectrum, and impact on life expectancy of malignant tumors all exhibited gender differences. Males are a key population, and lung cancer, urinary system, and digestive tract malignancies are the priorities for prevention and control. Targeted cancer prevention and control strategies should be developed based on the gender differences in malignant tumors and the changes in the population mortality spectrum |
