| [Objective]?To analyze the incidence, mortality, and temporal trends of oral and Pharyngeal cancer in the cancer registration regions of Zhejiang Province from 2000 to 2021, providing evidence for prevention and control strategies.[Methods]?Data on oral and Pharyngeal cancer incidence and mortality were collected from the cancer registration regions of Zhejiang Province in 2000–2021. Crude incidence/mortality rates, age-standardized rates (Chinese standard population: ASIRC/ASMRC; world standard population: ASIRW/ASMRW), and average annual percentage changes (AAPC) with 95% confidence intervals (CIs) were calculated.[Results]?In 2021, the crude incidence, ASIRC, and ASIRW of oral and Pharyngeal cancer were 5.54, 2.89, and 2.85 per 100,000, respectively, with the ASIRC in males 2.22 times higher than in females. The crude mortality, ASMRC, and ASMRW were 1.88, 0.81, and 0.82 per 100,000, respectively, showing a male ASMRC 3.32 times higher than females and urban male ASMRC 1.18 times higher than rural males. From 2000 to 2021, overall crude incidence, ASIRC, and ASIRW increased significantly,AAPC = 4.78%（95%CI：3.59-6.19，P＜0.001）, 2.62%（95%CI：1.83-3.92，P＜0.001）, and 2.60%（95%CI：1.84-3.82，P＜0.001）, respectively, with the highest AAPC observed in rural males. Similarly, crude mortality, ASMRC, and ASMRW showed upward trends, AAPC=4.81%（95%CI：3.54-6.01，P＜0.001）, 1.89%（95%CI：0.48-3.33，P=0.008）, and 2.01%（95%CI：0.27-4.43，P=0.030）, respectively,urban males had the highest AAPC. [Conclusion]?Oral and Pharyngeal cancer incidence and mortality in cancer registration regions of Zhejiang Province exhibited persistent growth from 2000 to 2021. Targeted interventions including health education, oral health campaigns, and enhanced screening,should prioritize males, particularly rural populations, while integrating three-level prevention strategies for comprehensive control. |
