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| 基于自噬分子机制的食管鳞状细胞癌治疗新策略 |
| A new therapeutic strategy for esophageal squamous cell carcinoma based on the molecular mechanism of autophagy |
| 投稿时间：2025-04-29 修订日期：2025-08-05 |
| DOI： |
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| 中文关键词: 自噬 分子机制 食管鳞状细胞癌 靶向治疗 |
| 英文关键词:Autophagy Molecular mechanisms Esophageal squamous cell carcinoma (ESCC) Targeted therapy |
| 基金项目:甘肃省自然科学基金（23JRRA1288） |
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| 中文摘要: |
| 摘要：[目的] 深入理解自噬在食管鳞状细胞癌（Esophageal squamous cell carcinoma, ESCC）中的双向调控网络，并为开发基于自噬调控的精准治疗策略提供理论依据和创新思路。[方法] 系统综述自噬的发生过程及其关键分子通路，并分析其与ESCC发生发展的关系。探讨ESCC细胞如何精细调控自噬活性以及这种调控如何影响肿瘤的生物学行为。从抑制保护性自噬克服治疗耐药、靶向自噬-凋亡通路实现协同致死、干预自噬介导细胞周期失调以抑制肿瘤生长三个方面，重点分析靶向自噬的ESCC联合治疗策略的研究进展。[结果] ESCC细胞通过精细调控自噬活性，一方面维持能量代谢稳态并塑造免疫抑制性肿瘤微环境，从而促进癌细胞的增殖与转移；另一方面抑制过度自噬以维持生存优势。靶向自噬的联合治疗策略在抑制ESCC增殖和转移方面具有潜在的应用价值。[结论] 自噬在ESCC中发挥着复杂的双向调控作用，其精准调控对ESCC的发生发展至关重要。靶向自噬的联合治疗策略为ESCC的治疗提供了新的方向。 |
| 英文摘要: |
| Abstract: [Objective] To gain an in-depth understanding of the dual regulatory network of autophagy in esophageal squamous cell carcinoma (ESCC) and to provide theoretical basis and innovative ideas for the development of precision treatment strategies based on autophagy regulation. [Methods] A systematic review of the process of autophagy and its key molecular pathways was conducted, and the relationship between autophagy and the development of ESCC was analyzed. The study explored how ESCC cells finely regulate autophagy activity and how this regulation affects the biological behavior of tumors. Research progress on ESCC combination treatment strategies targeting autophagy was analyzed in three aspects: inhibiting protective autophagy to overcome treatment resistance, targeting the autophagy-apoptosis pathway to achieve synthetic lethality, and intervening in autophagy-mediated cell cycle dysregulation to inhibit tumor growth. [Results] By finely regulating autophagic activity, ESCC cells maintain energy metabolism homeostasis and shape the immunosuppressive tumor microenvironment, thereby promoting the proliferation and metastasis of cancer cells. On the other hand, excessive autophagy is inhibited to maintain survival advantage. The combination therapy strategy of targeting autophagy has potential application value in inhibiting the proliferation and metastasis of ESCC. [Conclusion] Autophagy plays a complex bidirectional regulatory role in ESCC, and its precise regulation is crucial to the occurrence and developmentof ESCC. The combination therapy strategy of targeting autophagy provides a new direction for the treatment of ESCC. |
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