| Genetic testing plays a significant role in the diagnosis and treatment of cervical cancer. HPV DNA testing is the preferred method for screening healthy individuals. HPV E6/E7 mRNA reflects the activity state of HPV genes, and DNA methylation testing can identify patients at risk of cervical cancer or precancerous lesions of the cervix. The latter two can be used for the triage of HPV-positive patients. It is recommended that patients with Peutz-Jeghers syndrome undergo STK11 gene mutation testing to guide screening and treatment. For patients with advanced and recurrent metastatic cervical cancer, PD-L1, MMR/MSI, TMB testing, and HER2, RET, and NTRK gene testing are recommended to screen for eligible patients and guide precise treatment. |
