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| 肿瘤相关中性粒细胞与PD-1/PD-L1在胃癌的相关研究进展 |
| Recent Advances in the Mechanism of Action of Tumor-Associated Neutrophils and PD-1/PD-L1 in Gastric Cancer |
| 投稿时间：2025-03-29 修订日期：2025-06-05 |
| DOI： |
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| 中文关键词: 胃癌，肿瘤相关中性粒细胞，肿瘤微环境，PD-1/PD-L1。 |
| 英文关键词:gastric cancer, tumor-associated neutrophils, tumor microenvironment, PD-1/PD-L1. |
| 基金项目:甘肃省卫健委课题(GSWSKY2023-34)；兰州市青年科技人才创新项目(2024-QN-39) |
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| 中文摘要: |
| 胃癌（GC）是消化道常见恶性肿瘤，其具有较高的发病率及死亡率。近年来程序性死亡蛋白（PD-1）/程序性死亡蛋白配体（PD-L1）抑制剂因高疗效及低副作用等特性成为研究热点，并且随着对肿瘤微环境的深入研究，发现肿瘤相关中性粒细胞（TANs）能影响PD-1/PD-L1在胃癌中的治疗。本文讨论了TANs、PD-1/PD-L1与胃癌三者关系及免疫治疗的最新进展，阐明TANs影响PD-1/PD-L1在胃癌中的治疗及耐药的具体作用机制。此外，我们总结了 TANs与PD-1/PD-L1治疗胃癌的当前挑战，并探讨了提高其临床可行性和治疗影响的未来研究方向。 |
| 英文摘要: |
| Gastric cancer (GC) is a common malignant tumor of the digestive tract, characterized by high incidence and mortality rates. In recent years, programmed death protein (PD-1)/programmed death ligand (PD-L1) inhibitors have emerged as a research hotspot due to their high efficacy and low side effects. Furthermore, with the deepening understanding of the tumor microenvironment, it has been discovered that tumor-associated neutrophils (TANs) can influence the therapeutic efficacy of PD-1/PD-L1 in gastric cancer. This article discusses the relationship between TANs, PD-1/PD-L1, and gastric cancer, as well as the latest advances in immunotherapy. It elucidates the specific mechanisms by which TANs influence PD-1/PD-L1 therapy and drug resistance in gastric cancer. Additionally, we summarize the current challenges in using TANs and PD-1/PD-L1 therapy for gastric cancer and explore future research directions to enhance their clinical feasibility and therapeutic impact. |
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