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| 2012—2021年苏州市肿瘤登记地区上消化道癌发病和死亡分析 |
| Incidence and Mortality of Upper Gastrointestinal Cancers in Suzhou City from 2012 to 2021 |
| 投稿时间：2025-02-21 修订日期：2025-06-03 |
| DOI： |
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| 中文关键词: 上消化道癌 食管癌 胃癌 发病率 死亡率 |
| 英文关键词:upper gastrointestinal cancer esophageal cancer gastric cancer incidence rates mortality rates |
| 基金项目:苏州市姑苏卫生人才科研项目（GSWS2023066）；江苏省老年健康科研项目（LKM2023038）；苏州市重大疾病、传染病预防和控制关键技术（研究）项目，GWZX202301；苏州市科技发展计划(医疗卫生科技创新)项目（SKYD2022007，SKYD2023161） |
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| 中文摘要: |
| 摘要：[目的]分析苏州市肿瘤登记地区2012—2021年上消化道癌发病和死亡变化趋势。[方法]收集2012—2021年苏州市上消化道癌发病和死亡信息，计算上消化道癌的发病和死亡粗率、中标率,采用 Joinpoint 对数线性回归模型分析上消化道癌的发病和死亡的变化趋势，计算平均年度变化百分比。[结果] 2012—2021年苏州市上消化道癌发病粗率为64.97/10万，中标率29.33/10万。其中男性中标率43.02/10万，女性16.57/10万，男性是女性的2.60倍。上消化道癌发病率整体呈下降趋势,中标率的AAPC为-4.96%（95%CI：-5.66%~-4.26%）。2012—2021年苏州市上消化道癌死亡粗率为45.25/10万，中标死亡率19.03/10万。其中男性中标死亡率28.87/10万，女性10.08/10万，男性是女性的2.86倍。上消化道癌死亡率整体呈下降趋势，中标死亡率的AAPC为-4.44%（95%CI：-5.55%~-3.32%）。其中食管癌发病粗率为15.22/10万，中标率6.47/10万，死亡粗率为12.38/10万，中标死亡率5.01/10万；胃癌发病粗率为49.75/10万，中标率22.85/10万，死亡粗率为32.87/10万，中标死亡率14.02/10万。食管癌、胃癌发病率和死亡率均呈下降趋势。[结论]苏州市肿瘤登记地区上消化道癌发病率和死亡率整体呈下降趋势,男性上消化道癌发病率和死亡率均高于女性。尽管食管癌、胃癌的发病率和死亡率近年整体呈下降趋势，但上消化道癌的疾病负担依然较重，需针对重点人群，综合施策，进一步开展上消化道癌的防治工作。 |
| 英文摘要: |
| [Objective] To analyze the trends of the incidence and mortality of upper gastrointestinal cancer (UGIC) in the cancer registration areas of Suzhou City from 2012 to 2021. [Methods] Data on upper gastrointestinal cancer cases in Suzhou City from 2012 to 2021 were collected. The crude incidence/mortality rates and age-standardized incidence/mortality rates by Chinese standard population (ASIRC/ASMRC) of UGIC were calculated. The change trends of UGIC incidence and mortality were analyzed by the Joinpoint log-linear regression model, and the average annual percentage change (AAPC) were calculated. [Results] From 2012 to 2021, the crude incidence rate, and ASIRC of UGIC in Suzhou City was 64.97/105, 29.33/105, respectively. The ASIRC was 43.02/105 for males and 16.57/105 for females, indicating that the incidence rate in males was 2.60 times higher than that in females. The overall incidence of UGIC showed a declining trend, with an AAPC of ASIRC of -4.96% (95%CI: -5.66%~-4.26%). During the same period, the crude mortality rate, ASMRC of UGIC was 45.25/105, 19.03/105, respectively， the ASMRC was 28.87/105 for males and 10.08/105 for females, indicating that the mortality rate in males was 2.86 times higher than that in females. The overall mortality of UGIC also showed a declining trend, with an AAPC of ASMRC of -4.44% (95%CI: -5.55%~-3.32%). Specifically, For esophageal cancer ,the crude incidence rate, ASIRC, crude mortality rate, ASMRC was 15.22/105, 6.47/105, 12.38/105, 5.01/105, respectively. For gastric cancer, the crude incidence rate, ASIRC, crude mortality rate, ASMRC was 49.75/105, 22.85/105,32.87/105, 14.02/105, respectively. Both the incidence and mortality rates of esophageal and gastric cancers showed declining trends. [Conclusion] The incidence and mortality rates of UGIC in the tumor registration areas of Suzhou City from 2012 to 2021 showed an overall decreasing trend, with higher rates among males than females. Although the incidence and mortality rates of esophageal and gastric cancers have declined in recent years, the disease burden of UGIC remains significant. Targeted interventions and comprehensive strategies should be implemented for high-risk populations to further strengthen the prevention and control of UGIC. |
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