抗体-药物偶联物在消化道肿瘤中的进展及展望
Progress and Prospects of Antibody-Drug Conjugates in Digestive Tract Tumors
投稿时间:2024-12-19  修订日期:2025-05-09
DOI:
中文关键词:  抗体-药物偶联物  消化道肿瘤  HER2  CLDN18.2  TROP2
英文关键词:Antibody-Drug Conjugate (ADC)  Gastrointestinal Malignancies  HER2  CLDN18.2  TROP2
基金项目:
作者单位邮编
焦好 北京大学肿瘤医院 100032
刘畅 北京大学肿瘤医院 
鲁智豪* 北京大学肿瘤医院 100142
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中文摘要:
      抗体-药物偶联物(Antibody-Drug Conjugate,ADC)是一种创新的癌症治疗策略。近年来,随着生物制药技术的发展,ADC在消化道肿瘤的治疗中显示出巨大的潜力。本文系统综述了ADC在消化道肿瘤领域的研究现状,分析了关键靶点及代表性药物的临床进展,探讨了ADC优化策略与未来发展方向,旨在为ADC在消化道肿瘤中的应用提供参考与启示。
英文摘要:
      Antibody-drug conjugate (ADC) represents an innovative cancer treatment strategy. In recent years, with the advancement of biopharmaceutical technologies, ADC has demonstrated great potential in the treatment of gastrointestinal malignancies This article systematically reviews the current research status of ADC in the field of gastrointestinal malignancies, analyzes key targets and representative drugs in clinical development, and discusses optimization strategies and future directions, aiming to provide insights and references for the application of ADC in gastrointestinal malignancies.
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