| Trophoblast cell surface antigen-2 (Trop-2), encoded by the tumor-associated calcium signal transducer 2 (TACSTD2) gene, is a cell surface glycoprotein whose structure comprises a leader sequence, an extracellular domain, a transmembrane domain, and an intracellular tail region. It functions in regulating signal transduction and influencing the cell cycle. Trop-2 is highly expressed in gynecological tumors such as ovarian cancer, cervical cancer, and endometrial cancer, and it is associated with tumor malignancy, prognosis, and metastasis risk. By activating signaling pathways, Trop-2 promotes tumor proliferation and migration andexhibits stem-cell-like properties. Antibody-drug conjugates (ADCs) targeting Trop-2, such as sacituzumab govitecan (SG), have demonstrated efficacy in clinical trials, particularly against Trop-2-positive gynecological tumor cells. Trop-2 holds significant potential as a therapeutic target, offering new treatment options and strategies for gynecological malignancies. |
