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| 组蛋白去甲基酶KDM3B在癌症中的研究进展 |
| Research progress of histone demethylase KDM3B in cancer |
| 投稿时间：2024-11-22 修订日期：2025-03-01 |
| DOI： |
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| 中文关键词: KDM3B 表观遗传学 癌症 治疗靶点 |
| 英文关键词:KDM3B Epigenetics Cancer Therapeutic targets |
| 基金项目:KDM3B经SCL7A11调控铁死亡对卵巢癌预后影响的机制研究 |
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| 中文摘要: |
| 癌症的发生既往认为需要一系列基因突变,且突变有利于不可控的肿瘤生长。表观遗传学的出现给癌症发生提供了另一个潜在原因。表观遗传机制对基因表达的时间和空间控制对所有生物过程都是必不可少的,因此,表观遗传失调通常会导致包括癌症在内的多种疾病。组蛋白甲基化和去甲基化修饰是表观遗传学广泛且重要的调控机制之一。组蛋白赖氨酸甲基化和去甲基化与染色质激活和抑制有关, 其甲基化活性不仅取决于赖氨酸残基被靶向的位点及甲基化程度,而且与赖氨酸甲基化发生的基因区域有关。其中,组蛋白H3K9甲基化和去甲基化是目前研究最深入的组蛋白修饰之一。组蛋白去甲基酶KDM3B((histone demethylase 3B)是一种重要的表观遗传调控因子,它通过特异性去除组蛋白H3K9的甲基化修饰来调控基因表达。近年来,KDM3B在多种生物学过程和疾病中的功能作用受到了广泛关注,尤其是在癌症中,其在不同的癌症类型中扮演重要角色,表现出不一致性,直接或间接抑制或促进癌症的发生。本综述中我们讨论KDM3B的功能及在相关癌症中发生发展的作用及潜在治疗靶点,以希望指导开发新型表观遗传药物。 |
| 英文摘要: |
| In the past, it was thought that a series of genetic mutations were required for the development of cancer, and the mutations were conducive to uncontrollable tumor growth. The advent of epigenetics provides another potential cause for cancer. Temporal and spatial control of gene expression by epigenetic mechanisms is essential for all biological processes, and as a result, epigenetic dysregulation often leads to a variety of diseases, including cancer. Histone methylation and demethylation modifications are one of the extensive and important regulatory mechanisms of epigenetics. Histone lysine methylation and demethylation are related to chromatin activation and repression, and their methylation activity depends not only on the site and degree of methylation of lysine residues, but also on the gene region where lysine methylation occurs. Among them, histone H3K9 methylation and demethylation are one of the most deeply studied histone modifications. Histone demethylase KDM3B (histone demethylase 3B) is an important epigenetic regulator that regulates gene expression by specifically removing methylation modifications of histone H3K9. In recent years, the functional role of KDM3B in a variety of biological processes and diseases has received extensive attention, especially in cancer, where it plays an important role in different cancer types, exhibiting inconsistencies that directly or indirectly inhibit or promote the occurrence of cancer. In this review, we discuss the function and development of KDM3B in related cancers, as well as potential therapeutic targets, with the hope of guiding the development of novel epigenetic drugs. |
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