血脂水平与乳腺癌风险及预后相关性的研究进展
Research progress on the correlation between blood lipid level with risk and prognosis of breast cancer
投稿时间:2024-09-25  修订日期:2024-11-10
DOI:
中文关键词:  乳腺癌  血清脂质  甘油三酯  总胆固醇  高密度脂蛋白  低密度脂蛋白
英文关键词:Breast cancer  Serum lipids  Triglyceride  Total cholesterol  High density lipoprotein cholesterol  Low density lipoprotein cholesterol
基金项目:广东省普通高校认定类科研项目(2021KTSCX037);湛江市科技发展专项资金竞争性分配项目(2023A206,2023A207);湛江市科学技术局科技计划项目(2022A01190)
作者单位邮编
周桂平 广东医科大学 524000
滕玥玥 广东医科大学 524000
施世明 广东医科大学附属医院 524000
黄胜超 广东医科大学附属医院 524000
张远起 广东医科大学附属医院 524000
李建文* 广东医科大学附属医院 524000
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中文摘要:
      乳腺癌是全球女性最常见的癌症类型,也是女性癌症死亡的主要原因,因此明确风险因素对乳腺癌诊断乃至改善患者预后有着重要的作用。而绝大部分乳腺癌患者因月经状态改变而导致体内雌激素水平明显下降,进而导致血脂水平异常,因此血脂水平可能是可改变的乳腺癌风险因素。在本综述中,我们回顾了迄今为止关于主要甘油三脂(TG)、总胆固醇(TC)、低密度和高密度脂蛋白胆固醇 (LDL-C 和 HDL-C) 等血脂代谢水平与乳腺癌发生发展的研究,发现血脂水平与乳腺癌风险之间的关系是一个活跃的研究领域,尽管有许多研究探讨了血脂水平与乳腺癌的关联,但研究结果仍存在争议。同时,我们还发现研究血脂代谢在乳腺癌中的作用机制,有望为乳腺癌治疗提供新靶点,进一步改善预后,延长患者的生存时间。最后,监测乳腺癌的血脂水平并使用调脂类药物进行血脂管理,对改善乳腺癌患者的预后及防止心血管疾病有一定的益处,但仍需更多的研究证据来支持这些发现。
英文摘要:
      Breast cancer is the most common type of cancer in women around the world, and it is also the main cause of cancer death in women. Therefore, identifying risk factors plays an important role in breast cancer diagnosis and even improving the prognosis of patients. However, in most breast cancer patients, the estrogen level in the body drops significantly due to the change of menstrual status, which leads to abnormal blood lipid level. Therefore, blood lipid level may be a changeable risk factor for breast cancer. In this review, we reviewed the studies to date on the metabolic levels of blood lipids such as major triglycerides (TG), total cholesterol (TC), low-density and high-density lipoprotein cholesterol (LDL-C and HDL-C) and the occurrence and development of breast cancer, and found that the relationship between blood lipids and breast cancer risk is an active research area. Although many studies have explored the association between blood lipids and breast cancer, the findings are still controversial. At the same time, we also found that studying the mechanism of blood lipid metabolism in breast cancer is expected to provide a new target for breast cancer treatment, further improve the prognosis and prolong the survival time of patients. Finally, monitoring the blood lipid level of breast cancer and using lipid-lowering drugs for blood lipid management have certain benefits in improving the prognosis of breast cancer patients and preventing cardiovascular diseases, but more research evidence is still needed to support these findings.
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