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| 三级淋巴结构在妇科肿瘤中的研究进展 |
| Research progress of tertiary lymphoid structure in gynecological cancers |
| 投稿时间：2024-06-19 修订日期：2024-07-17 |
| DOI： |
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| 中文关键词: 三级淋巴结构 妇科肿瘤 预后 肿瘤免疫治疗 |
| 英文关键词:Tertiary lymphoid structure Gynecological cancers Prognosis Tumor immunotherapy |
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| 中文摘要: |
| 三级淋巴结构（tertiary lymphoid structure，TLS）是在肿瘤、慢性感染、自身免疫性疾病等病理环境的刺激下，在非淋巴组织中形成的异位淋巴细胞聚集体。它与包括妇科肿瘤在内的多种实体肿瘤的良好预后有关。通过对TLS不同状态在肿瘤中的研究，如密度、位置、成熟度及内部特征等可以预测不同肿瘤患者的临床预后和免疫治疗反应。且目前通过诱导肿瘤相关TLS形成来促进抗肿瘤免疫产生和维持已作为一种新兴的免疫治疗方法。本文将从TLS的形成、评估方法、在不同妇科肿瘤中的预后作用及治疗中的价值进行综述。 |
| 英文摘要: |
| Tertiary lymphoid structure (TLS) is an aggregate of ectopic lymphoid cells formed in non-lymphoid tissues under the stimulation of pathological environment such as tumors、chronic infections and autoimmune diseases. It is associated with a favorable prognosis for a variety of solid tumors, including gynecological tumors. The study of different TLS states in tumors, such as density、location、maturity and internal characteristics can predict the clinical prognosis and immunotherapy response of patients with different tumors. At present, inducing tumor-associated TLS formation to promote the production and maintenance of anti-tumor immunity has been used as a new immunotherapy method. This article will review the formation、evaluation methods、prognostic effect and therapeutic value of TLS in different gynecological tumors. |
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