| PURPOSE The COL5A1 gene encodes a low abundance fibrillar collagen α However, the regulation of the tumor microenvironment and its impact on the prognosis of patients with tumors are currently unclear. This study mainly explores the role of COL5A1 gene in the prognosis and tumor immunology of pan cancer. METHOD In this study, we analyzed cancer patients from the cancer genome atlas (TCGA) database. Analyze the COL5A1 gene and its relationship with pan oncogenes using TIMER2.0, GEPIA2, Sangerbox, human protein atlas (HPA), and STRING. RESULT This study found that there were differences in the expression levels of COL5A1 in 17 different types of cancer and adjacent tissues, which affected the prognosis of 9 types of cancer patients. In addition, the expression of COL5A1 is significantly correlated with tumor microenvironment (TME), immune checkpoints (ICP), tumor mutation burden (TMB), and microsatellite instability (MSI) in human cancer. In addition, COL5A1 positive expression is associated with immune infiltration of B cells, T cells, neutrophils, macrophages, and antigen-presenting cells. CONCLUSION COL5A1 is an important component of TME, affecting immune cell infiltration and making it an important tumor marker for evaluating immune infiltration and prognostic analysis in many malignant tumors. |
