| 吴江,朱虹,王中秋,张新华,章如松,卢光明.基于D2-40检测胰腺癌组织中淋巴管密度的价值[J].肿瘤学杂志,2010,16(2):. |
| 基于D2-40检测胰腺癌组织中淋巴管密度的价值 |
| The Value of Detecting Lymphatic Vessel Density with D2-40 in Pancreatic Carcinoma Tissues |
| 中文关键词 |
| DOI：10.11735/j.issn.1671-170X.2010.2.043 |
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| 中文关键词: 胰腺肿瘤 D2-40 淋巴管密度 免疫组织化学 |
| 英文关键词:pancreatic neoplasms D2-40 lymphatic vessel density immunohistochemically |
| 基金项目:国家自然科学基金(30870689); 江苏省自然科学基金(BK2008325) |
| 吴江 朱虹 王中秋 张新华 章如松 卢光明 |
| 南京军区南京总医院; |
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| 中文摘要: |
| [目的]探讨胰腺癌组织中淋巴管密度与肿瘤恶性程度、淋巴转移的相关性。[方法]应用免疫组化方法,采用单克隆抗体D2-40检测经手术切除的33例胰腺癌组织的瘤周淋巴管密度(pLVD)和瘤内淋巴管密度(iLVD),分析胰腺癌组织pLVD、iLVD与患者临床病理参数之间的关系。[结果]胰腺癌的pLVD明显高于iLVD。胰腺癌的pLVD与肿瘤的分化程度、淋巴结转移及淋巴管累及明显相关,与年龄、性别、肿块大小、发生部位、浸润侵犯无关。[结论]胰腺癌中检测pLVD较iLVD更有价值;上述pLVD可以预测淋巴结转移,有助于判断预后。 |
| 英文摘要: |
| [Purpose] To investigate the relationship of lymphatic vessel density with malignant aggressiveness and lymphatic metastasis in pancreatic carcinoma tissues.[Methods] The lymphatic vessel density(LVD) of intratymor(iLVD) and peritumor areas(pLVD) in 33 surgical samples from pancreatic carcinoma tissues were detected by immunohistochemically(with monoclonal antibody D2-40).The relationship between iLVD,pLVD and clinicopathological parameters was analyzed.[Results] The pLVD was significantly higher than the i... |
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