| 龚琴,区锦燕,廖荣宗,罗富荣,邹功胜,胡兴国,曾因明.鞘内注射PI3K特异性抑制剂LY294002对小鼠骨癌痛的影响[J].肿瘤学杂志,2010,16(1):. |
| 鞘内注射PI3K特异性抑制剂LY294002对小鼠骨癌痛的影响 |
| Effect of Intrathecal Injection with PI3K Specific Inhibitor(LY294002) on Mice with Bone Cancer Pain |
| 中文关键词 |
| DOI：10.11735/j.issn.1671-170X.2010.1.010 |
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| 中文关键词: 骨癌痛 脊髓 LY294002 小鼠 |
| 英文关键词:bone cancer pain spinal cord LY294002 mice |
| 基金项目:广东省卫生厅基金资助课题(A2008680) |
| 龚琴 区锦燕 廖荣宗 罗富荣 邹功胜 胡兴国 曾因明 |
| 广东省佛山市中医院;徐州医学院江苏省麻醉医学研究所; |
| 摘要点击次数: 2025 |
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| 中文摘要: |
| [目的]了解鞘内注射PI3K特异性抑制剂LY294002对小鼠股骨癌痛的影响。[方法]C3H/HeJ小鼠32只,随机分为对照组、假手术组、骨癌组和鞘内LY294002+骨癌组(抑制剂组),每组8只,分别于造模前和模型建立后的第8、10、12、14、17、21d测定各小鼠机械痛敏(机械缩腿阈值,mechanical withdrawal threshold,MWT)和热痛敏(热缩腿潜伏期,thermal withdrawal latency,TWL),LY294002术前鞘内注射。[结果]与术前相比较,骨癌组小鼠术后12、14、17、21dMWT明显下降(t=4.527,P=0.003;t=3.698,P=0.008;t=4.043,P=0.005;t=4.309,P=0.004),TWL明显降低(t=5.946,P=0.001;t=5.214,P=0.001;t=6.786,P=0.000;t=5.758,P=0.001);与假手术组相比较,骨癌组小鼠术后12、14、17、21dMWT明显下降(P=0.027;P=0.000;P=0.000;P=0.000),TWL明显降低(P=0.000;P=0.000;P... |
| 英文摘要: |
| [Purpose] To investigate the effect of intrathecal injection PI3K specific inhibitor(LY294002) on mice with bone cancer pain.[Methods] Thirty-two C3H/HeJ mice were randomly divided into 4 groups(n=8 each):control group,sham operation group,bone cancer group,bone cancer +LY294002 group.The mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) were measured at the time of pre-operation and the 8d,10d,12d,14d,17d,21d post operation.LY294002 was intrathecal injection before operation.[Results... |
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