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| 腹腔常温化疗联合深部热疗对胃癌术后患者辅助治疗的应用效果评价 |
| Evaluation of the Efficacy of Normothermic Intraperitoneal Chemotherapy Combined with Deep Hyperthermia as Adjuvant Treatment in Postoperative Gastric Cancer Patients |
| 投稿时间：2025-09-04 修订日期：2026-01-05 |
| DOI： |
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| 中文关键词: 腹腔常温灌注化疗、深部热疗、胃癌术后辅助治疗 |
| 英文关键词:NIPEC,Radiofrequency Deep Hyperthermia,Adjuvant Therapy for Gastric Cancer after Surgery |
| 基金项目:基金项目：镇江市科技计划资助（SH2024057） |
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| 中文摘要: |
| 目的 探讨NIPEC联合深部热疗对进展期胃癌术后患者的临床疗效。方法 招募130例进展期胃癌患者，随机分为试验组和对照组，每组各65例。对照组采用SOX方案术后辅助化疗，试验组采用SOX方案术后辅助化疗联合紫杉醇NIPEC及深部热疗，比较分析两组患者的2年DFS、安全性、危险因素分析、胆汁酸以及NLR水平。结果 试验组和对照组2年DFS率分别为80%、55.4%，具有显著统计学差异（P＜0.001），且临床Ⅲ期的患者对本干预方案的敏感性更高（P＜0.001）；治疗前后血清胆汁酸水平，试验组分别为7.38±10.18μmmol/L、4.01±5.11μmmol/L（P=0.001），对照组治疗前后分别为7.63±8.42μmmol/L、6.90±8.47μmmol/L（P=0.340）。治疗前后NLR，试验组分别为7.38±10.18、1.42±0.78（P<0.001），对照组分别为1.78±1.26、1.77±1.09（P=0.977）。单因素及多因素Cox回归分析表明，术后化疗方式（P=0.001）以及胃癌N分期（P=0.008）是影响患者2年DFS的主要危险因素；试验组和对照组安全性评价比较差异无统计学意义（P＞0.05）。结论 腹腔常温化疗联合深部热疗是进展期胃癌术后辅助治疗的有效疗法。 |
| 英文摘要: |
| Objective To explore the clinical efficacy of NIPEC combined with deep hyperthermia in patients with advanced gastric cancer after surgery. Methods A total of 130 patients with advanced gastric cancer were recruited and randomly divided into the experimental group and the control group, with 65 cases in each group. The control group received pDFStoperative adjuvant chemotherapy with the SOX regimen, while the experimental group received pDFStoperative adjuvant chemotherapy with the SOX regimen combined with paclitaxel NIPEC and deep hyperthermia. The 2-year disease-free survival, safety, risk factor analysis, bile acid and NLR levels of the two groups were compared and analyzed. Results The 2-year disease-free survival rates of the experimental group and the control group were 80% and 55.4% respectively, with a significant statistical difference (P < 0.001), and patients in clinical stage III were more sensitive to this intervention plan (P < 0.001). The serum bile acid levels before and after treatment in the experimental group were 7.38±10.18μmmol/L and 4.01±5.11μmmol/L respectively (P=0.001), and thDFSe in the control group before and after treatment were 7.63±8.42μmmol/L and 6.90±8.47μmmol/L respectively (P=0.340). The NLR before and after treatment was 7.38±10.18 and 1.42±0.78 respectively in the experimental group (P<0.001), and 1.78±1.26 and 1.77±1.09 respectively in the control group (P=0.977). Univariate and multivariate Cox regression analyses indicated that the pDFStoperative chemotherapy method (P=0.001) and the N stage of gastric cancer (P=0.008) were the main risk factors affecting the disease-free survival of patients within 2 years. However, there was no statistically significant difference in the safety evaluation between the experimental group and the control group (P > 0.05). Conclusion Intraperitoneal normotheric chemotherapy combined with deep hyperthermia is an effective adjuvant therapy for advanced gastric cancer after surgery. |
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