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| 碳离子放射治疗Ⅲ期非小细胞肺癌的临床疗效与安全性分析 |
| Clinical efficacy and safety analysis of carbon ion radiotherapy for stage III non-small cell lung cancer |
| 投稿时间：2025-11-28 修订日期：2025-12-15 |
| DOI： |
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| 中文关键词: 碳离子放疗 Ⅲ期肺癌 非小细胞肺癌 临床疗效 不良反应 预后 |
| 英文关键词:Carbon ion radiotherapy Stage III lung cancer Non-small cell lung cancer Clinical efficacy Adverse reactions Prognosis |
| 基金项目:甘肃省自然科学基金(23JRRH0006)；陇原青年创新创业人才基金(2021LQTD14)；甘肃中医药大学研究生创新基金 |
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| 摘要点击次数: 55 |
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| 中文摘要: |
| [目的]评估国产碳离子系统放射治疗Ⅲ期非小细胞肺癌的有效性与安全性，分析疾病预后相关影响因素，为临床决策提供参考。[方法]收集并分析2020年3月至2023年7月甘肃省武威肿瘤医院进行碳离子放射治疗的Ⅲ期非小细胞肺癌患者的临床资料及随访数据。采用Kaplan‐Meier法分析患者的局部控制（LCR）率、无进展生存（PFS）率及总生存（OS）率，log‐rank法进行差异检验。[结果]44例患者中位随访时间18(3~48)个月。1年和2年的OS率为81.82%、61.36%%，PFS率为100.00%、95.45%，LCR率为100.00%、93.18%。放疗后不良反应发生率为52.27%，其中发生放射性食管炎17例(38.64%)、放射性皮炎5例(11.36%)、放射性肺炎3例(6.82%)，仅出现1例Ⅳ级放射性皮炎，其他患者未出现Ⅲ级及以上的不良反应。[结论]国产碳离子系统放射治疗Ⅲ期非小细胞肺癌在保障较好临床效果的同时，有效控制严重不良反应的发生风险，但仍需更大的样本量和更长的随访时间，以便开展进一步评估。 |
| 英文摘要: |
| [Objective] To evaluate the efficacy and safety of a domestic carbon-ion radiotherapy system for stage III non-small cell lung cancer (NSCLC) and to analyze factors influencing disease prognosis, thereby providing a reference for clinical decision-making. [Methods] Clinical data and follow-up information of patients with stage III NSCLC who underwent carbon-ion radiotherapy at Gansu Wuwei Cancer Hospital from March 2020 to July 2023 were collected and analyzed. The Kaplan-Meier method was used to calculate local control (LCR), progression-free survival (PFS), and overall survival (OS) rates. Differences were compared using the log-rank test. [Results] The median follow-up time for the 44 patients was 18 months (range: 3-48 months). The 1-year and 2-year OS rates were 81.82% and 61.36%, respectively. The 1-year and 2-year PFS rates were 100.00% and 95.45%, respectively. The 1-year and 2-year LCR rates were 100.00% and 93.18%, respectively. The incidence of adverse reactions after radiotherapy was 52.27%, including radiation esophagitis in 17 cases (38.64%), radiation dermatitis in 5 cases (11.36%), and radiation pneumonitis in 3 cases (6.82%). Only one case of grade IV radiation dermatitis was observed; no other patients experienced grade III or higher adverse reactions. [Conclusion] Treatment of stage III NSCLC with the domestic carbon-ion radiotherapy system demonstrates favorable clinical outcomes and a low incidence of severe adverse reactions. However, larger sample sizes and longer follow-up periods are required for further evaluation. |
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