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| 食管癌组织中α-SMA，CD34和Ki-67表达及与脉管侵犯关系 |
| Expression of α-SMA, CD34, and Ki-67 in Esophageal Cancer Tissues and Their Relationship with Vascular Invasion |
| 投稿时间：2025-07-18 修订日期：2025-09-26 |
| DOI： |
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| 中文关键词: 食管癌 α-平滑肌肌动蛋白 CD34 Ki-67 脉管侵犯 |
| 英文关键词:Esophageal cancer α-Smooth Muscle Actin CD34 Ki-67 Vascular invasion. |
| 基金项目:河南省卫生健康委员会项目(编号:LHGJ20210944) |
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| 中文摘要: |
| 目的:探讨食管癌组织中α-平滑肌肌动蛋白(α-SMA)、CD34和Ki-67的表达情况及其与脉管侵犯的关系。方法:选取2021年1月至2024年12月我院收治的97例食管癌患者为研究对象,收集其癌组织及癌旁正常组织标本。检测组织中α-SMA、CD34、Ki-67的表达水平。再根据患者有无脉管侵犯分为脉管侵犯组39例(40.21%)与无脉管侵犯组58例(59.79%),比较临床资料,Logistic回归分析影响食管癌患者脉管侵犯的因素,受试者操作特征(ROC)曲线评估α-SMA、CD34、Ki-67表达对食管癌患者脉管侵犯的诊断价值。结果:癌组织中α-SMA、CD34、Ki-67阳性细胞率均高于癌旁组织(P<0.05)。脉管侵犯组TNM分期III-IV期、低分化、淋巴结转移、α-SMA高表达、CD34高表达、Ki-67高表达的比例均高于无脉管侵犯组(P<0.05)。Logistic回归分析显示,TNM分期、分化程度、淋巴结转移、α-SMA高表达、CD34高表达、Ki-67高表达是食管癌患者脉管侵犯的影响因素(P<0.05)。α-SMA、CD34、Ki-67及联合检测对食管癌患者脉管侵犯的诊断的曲线下面积分别为0.721、0.669、0.703、0.864。结论:α-SMA、CD34和Ki-67在食管癌组织中高表达,且与脉管侵犯密切相关,可作为预测脉管侵犯的潜在生物标志物,联合检测可提高诊断准确性。 |
| 英文摘要: |
| Objective To investigate the expression of α-smooth muscle actin (α-SMA), CD34, and Ki-67 in esophageal cancer tissues and their relationship with vascular invasion. Methods A total of 97 patients with esophageal cancer treated in our hospital from January 2021 to December 2024 were selected as the study subjects. Cancer tissues and adjacent normal tissues were collected. The expression levels of α-SMA, CD34, and Ki-67 in the tissues were detected. The patients were further divided into a vascular invasion group (39 cases, 40.21%) and a non-vascular invasion group (58 cases, 59.79%) based on the presence or absence of vascular invasion.? Clinical data were compared, and logistic regression analysis was performed to identify factors influencing vascular invasion in esophageal cancer patients. The diagnostic value of α-SMA, CD34, and Ki-67 expression for vascular invasion in esophageal cancer patients was assessed using receiver operating characteristic (ROC) curve analysis. Results The positive cell rates of α-SMA, CD34, and Ki-67 in cancer tissues were significantly higher than those in adjacent tissues (P<0.05). The proportion of TNM stage III-IV, poor differentiation, lymph node metastasis, high expression of α-SMA, high expression of CD34, and high expression of Ki-67 were all higher in the vascular invasion group compared to the non-vascular invasion group (P<0.05). Logistic regression analysis showed that TNM stage, degree of differentiation, lymph node metastasis, high expression of α-SMA, high expression of CD34, and high expression of Ki-67 were influencing factors for vascular invasion in esophageal cancer patients (P<0.05). The areas under the curve for the diagnosis of vascular invasion in esophageal cancer patients by α-SMA, CD34, Ki-67, and combined detection were 0.721, 0.669, 0.703, and 0.864, respectively. Conclusion α-SMA, CD34, and Ki-67 are highly expressed in esophageal cancer tissues and are closely associated with vascular invasion, which can serve as potential biomarkers for predicting vascular invasion. Combined detection can improve diagnostic accuracy. |
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