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| 肺腺鳞癌的分子起源与临床诊疗研究进展 |
| Research Progress on Molecular Origin and Clinical Diagnosis and Treatment of Adenosquamous Carcinoma of the Lung |
| 投稿时间：2025-08-03 修订日期：2025-09-19 |
| DOI： |
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| 中文关键词: 肺腺鳞癌 发生机制 临床病理特征 预后 化疗 靶向治疗 免疫治疗 |
| 英文关键词:adenosquamous carcinoma of the lung, histogenesis, clinicopathological characteristics, prognosis, chemotherapy, targeted therapy, immunotherapy |
| 基金项目:山东省医药卫生科技项目 |
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| 摘要点击次数: 261 |
| 全文下载次数: 9 |
| 中文摘要: |
| 肺腺鳞癌（adenosquamous carcinoma of the Lung, ASC）是一种罕见且高度侵袭性的非小细胞肺癌亚型，兼具腺癌与鳞癌成分，诊断需依赖术后完整标本的病理与免疫组化分析，预后明显差于单一亚型。该肿瘤同时包含腺癌和鳞癌成分，然而其临床特征与其他非小细胞肺癌存在显著差异，表明肺腺鳞癌并非两者的简单混合，而是具有独特分子表型的复杂癌种。目前对肺腺鳞癌的研究仍较匮乏，主要因其分子机制复杂且病理起源尚未明确。认知的不足限制了该肿瘤的早期诊断与治疗，迄今尚未形成成熟有效的治疗方案体系。深入研究肺腺鳞癌的分子特征与临床特点，不仅有助于理解肺癌表型转换、肿瘤发生起源及异质性等问题，更将推动其个体化诊治策略的发展。 |
| 英文摘要: |
| Adenosquamous carcinoma of the lung (ASC) is a rare and highly aggressive subtype of non-small cell lung cancer (NSCLC), characterized by the presence of both adenocarcinoma and squamous cell carcinoma components. Diagnosis relies on postoperative pathological and immunohistochemical analysis of complete specimens, and the prognosis is significantly worse compared to single subtypes. This tumor contains both adenocarcinoma and squamous cell carcinoma components; however, its clinical features differ markedly from other types of non-small cell lung cancer, indicating that ASC is not merely a simple mixture of the two, but rather a complex cancer with a unique molecular phenotype. Research on ASC remains limited due to its complex molecular mechanisms and unclear pathological origin. The lack of understanding hinders early diagnosis and treatment, and no mature or effective treatment protocols have yet been established. In-depth study of the molecular characteristics and clinical features of ASC will not only aid in understanding issues such as lung cancer phenotype conversion, tumorigenesis, and heterogeneity, but also promote the development of personalized treatment strategies. |
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