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| NTRK融合及其靶向治疗药物在NSCLC中的研究进展 |
| Research Progress on NTRK Gene Fusion and Targeted Therapeutic Agents in Non-Small Cell Lung Cancer (NSCLC) |
| 投稿时间：2025-06-19 修订日期：2025-08-08 |
| DOI： |
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| 中文关键词: 非小细胞肺癌 NTRK基因融合 TRK抑制剂 靶向治疗 |
| 英文关键词:Non-small cell lung cancer (NSCLC) NTRK gene fusion TRK inhibitors Targeted therapy |
| 基金项目:天津中医药大学第一附属医院“拓新工程”基金 |
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| 中文摘要: |
| 本文全面综述了NTRK基因融合在NSCLC中的研究进展,涵盖基础理论、临床表现与诊断、靶向治疗应用、挑战与争议以及未来展望等方面。NTRK基因融合作为NSCLC的一种重要驱动因子,其发生率虽低,但对肿瘤的发生发展具有关键作用。文中详细阐述了NTRK基因融合的分子机制、NSCLC中NTRK融合的发生率与流行病学特征,比较了多种检测技术的应用及诊断方法,评估了NTRK靶向治疗药物的疗效与安全性,并探讨了治疗过程中面临的挑战以及未来的发展方向。通过对相关研究的综合分析,旨在为NSCLC中NTRK融合的临床诊疗和进一步研究提供全面的参考。 |
| 英文摘要: |
| This article provides a comprehensive review of the research progress on Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions in non-small cell lung cancer (NSCLC), encompassing fundamental theory, clinical presentation and diagnostic approaches, applications in targeted therapy, challenges and controversies, and future perspectives. Although occurring at a low frequency, NTRK gene fusions represent an important driver alteration in NSCLC, playing a pivotal role in tumorigenesis and progression. The review elaborates in detail on the molecular mechanisms underlying NTRK fusions, their incidence and epidemiological characteristics in NSCLC, compares various detection methodologies and diagnostic techniques, evaluates the efficacy and safety profiles of NTRK-targeted therapeutic agents, and discusses the challenges encountered during treatment, along with future directions. Through a comprehensive analysis of relevant research, this review aims to serve as a thorough reference for the clinical management and further investigation of NTRK fusions in NSCLC. |
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