| Objective：To investigate the clinical significance of relevant chemokines in the tumor microenvironment of papillary thyroid carcinoma (PTC) combined with Hashimoto"s thyroiditis (HT).
Methods：The pathological sections of 60 patients with papillary thyroid cancer from May to October 2023 in Zhejiang Provincial People"s Hospital , and were divided into PTC with HT group, PTC without HT group, Lymph Node Metastases (LNM) PTC with HT group and LNM PTC without HT group. Clinical data such as age of onset, gender, tumour size and clinicopathological characteristics of the four groups were compared. Protein chip identification was conducted in the early stage using the human chemokine microarray QAH-CHE-1. The expression of chemokines CCL21, CCL19, CCL8 and CXCL5 in the papillary thyroid cancer tissues of patients was detected by immunohistochemistry methods.
Results：It is more likely for HT to occur in women, and patients with PTC and HT have a higher incidence of extra-adenoidal invasion of the thyroid gland than patients without HT, with relatively larger tumour diameters. When lymph node metastasis was present, the incidence of multifocal tumour as well as extra-thyroidal gland invasion was higher, and the risk stratification also had an intermediate to high risk. The immunohistochemical results demonstrated that the positive expression rate of CCL21, CCL19, CCL8, and CXCL5 was higher in PTC tissues combined with HT than in PTC tissues not combined with HT. Furthermore, when there were lymph node metastases, the positive expression rate of PTC tissues combined with HT was even higher, with a statistically significant difference (P < 0.05).
Conclusion：Chemokines CCL21, CCL19, CCL8 and CXCL5 may be related to the role in the development of PTC against the backdrop of Hashimoto thyroiditis and the potential molecular mechanism. |
