亚力坤·穆罕默德,赵丽霞,朱开春.维、汉族HPV阳性妇女宫颈脱落细胞中L1蛋白的表达差异研究[J].中国肿瘤,2013,22(10):841-844.
维、汉族HPV阳性妇女宫颈脱落细胞中L1蛋白的表达差异研究
Expression of L1 Capsid Protein in Cervical Cells of HPV-Positive Uygur Women and Han Women
投稿时间:2013-03-27  
DOI:10.11735/j.issn.1004-0242.2013.10.A017
中文关键词:  HPV  HPVL1壳蛋白  液基细胞学  维吾尔族  汉族
英文关键词:HPV  HPV L1 capsid protein  liquid-based cytology  Uighur  Han
基金项目:国家自然科学基金(81160317)
作者单位
亚力坤·穆罕默德 新疆医科大学 
赵丽霞 新疆维吾尔自治区人民医院 
朱开春 新疆维吾尔自治区人民医院 
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中文摘要:
      摘 要:[目的] 探讨人乳头状瘤病毒( HPV) L1 壳蛋白在维、汉族HPV阳性宫颈不同病变脱落细胞中的表达。[方法] 收集宫颈脱落细胞标本 300 例,维吾尔族妇女129例:慢性宫颈炎64例(49%),CIN1 24例(19%),CIN2/3 26 例(20%),宫颈癌15例(12%);汉族妇女171例:慢性宫颈炎83例(48%),CIN1 39例(23%),CIN2/3 39例(23%),宫颈癌10例(6%)。采用免疫细胞化学法检测 HPV L1壳蛋白在宫颈脱落细胞中的表达。[结果] 维吾尔族妇女L1的表达阳性率为:慢性宫颈炎31%(20/64),CIN1 63% (15/24),CIN2/3 27% (7/26),宫颈癌中无表达,各组间比较差异有统计学意义 (χ2=17.466,P=0.01) ,且随病变程度加重(CIN到宫颈癌),HPV L1壳蛋白阳性表达率呈下降趋势。汉族妇女L1蛋白表达阳性率:慢性宫颈炎39%(32/83),CIN1 59% (23/39),CIN2/3 26% (10/39),宫颈癌中无表达。维吾尔族妇女与汉族妇女同级别宫颈病变间L1表达率差异均无统计学意义 (P均>0.05)。[结论] HPV L1 壳蛋白在宫颈病变中的阳性表达率随着病变程度加重呈下降趋势(CIN到宫颈癌),有望成为预测宫颈癌前病变进展的生物标志物。HPV L1壳蛋白在维、汉族同级别宫颈病变间的表达无差异。
英文摘要:
      Abstract:[Purpose] To investigate the expression of HPV L1 capsid protein in cervical cells of HPV-positive Uygur women and Han women.[Methods] Cervical cells specimens from 300 women were enrolled,including Uygur women 129 cases[chronic cervicitis 64 cases(49%);CIN1 24 cases (19%);CIN2/3 26 cases(20%) and cervical cancer 15 cases(12%)],and Han women 171 cases [chronic cervicitis 83 cases (48%),CIN1 39 cases (23%),CIN2/3 39 cases (23%) and cervical cancer 10 cases (6%)].The expression of HPV L1 capsid protein in cervical exfoliated cells were detected by immunocytochemical method.[Results] The positive rate of HPV L1 capsid protein in Uygur women was 31%(20/64) with chronic cervicitis;63%(15/24),CIN1;27%(7/26),CIN2/3 and negative expression with cervical cancer,with significant difference(χ2=17.446,P=0.01). The positive rate of HPV L1 capsid protein was reduced with the lesion progression from CIN to cancer. The positive rate of HPV L1 capsid protein in Han women was 39% (32/83) with chronic cervicitis;59%(23/39),CIN1;26%(10/39),CIN2/3 and negative expression with cervical cancer. In the same level of cervical lesions,there were no significant difference between Uyghur women and Han women(all P>0.05). [Conclusion] The positive rate of HPV L1 capsid protein decreases with the lesion progression from CIN to cervical cancer,it is expected to become biomarkers to predict the progression of cervical lesion. There are no significant differences of positive rate of HPV L1 protein between Uygur women and Han women with the same level of cervical lesions.
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