| 田 庆,吴玲玲,耿向甜,等.2017—2022年江苏省射阳县淮河流域肝癌高危人群队列筛查效果分析[J].中国肿瘤,2026,35(10):777-783. |
| 2017—2022年江苏省射阳县淮河流域肝癌高危人群队列筛查效果分析 |
| Screening Effectiveness in a Community-Based High-Risk Cohort for Liver Cancer in Sheyang County Within the Huaihe River Basin from 2017 to 2022 |
| 投稿时间：2026-05-12 |
| DOI：10.11735/j.issn.1004-0242.2026.10.A005 |
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| 中文关键词: 肝癌 早诊早治 生存 淮河流域 江苏 |
| 英文关键词:liver cancer early diagnosis and treatment survival Huaihe River Basin Jiangsu |
| 基金项目:江苏省疾病预防控制局科技计划项目（JSJK2026D00038）；盐城市卫健委医学科研立项项目（YK2025153） |
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| 中文摘要: |
| 摘 要：［目的］分析2017—2022年射阳县淮河流域肝癌高危人群队列筛查效果及成本效果。［方法］由既往乙肝表面抗原阳性人群组建高危人群队列，若人数不足则采用整群抽样方法，选取35~70岁常住居民参加问卷调查和乙肝表面抗原检测补充队列至2 000人。每年进行甲胎蛋白和B超检测。比较不同特征对象肝癌的发病密度、早诊率和生存率。根据直接筛查成本，开展卫生经济学评价。［结果］高危人群队列基线人员2 492人，共筛查12 405人次，累计筛查出80例肝癌患者，其中早期病例42例，早诊率为52.5%，男性发病密度显著高于女性，发病密度随年龄增长呈上升趋势。5年生存率为43.9%。每检出1例肝癌病例和早期肝癌病例的成本分别为52 150元和99 333元，早期发现成本系数为1.57。［结论］射阳县淮河流域肝癌高危人群队列筛查有较高肝癌早诊率和5年生存率，具有良好的卫生经济学价值，后续应加强男性人群筛查力度，尽早干预以提高患者生存率。 |
| 英文摘要: |
| Abstract： ［Purpose］ To evaluate the screening effectiveness and cost-effectiveness of a liver cancer high-risk cohort in the Huaihe River Basin of Sheyang County from 2017 to 2022. ［Methods］ A high-risk cohort was established from individuals with a prior positive hepatitis B surface antigen (HBsAg) test. When the sample size was insufficient， cluster sampling was used to recruit permanent residents aged 35-70 years old to participate in questionnaire surveys and HBsAg testing， supplementing the cohort to 2 000 individuals. Annual alpha-fetoprotein (AFP) testing and abdominal ultrasound examinations were performed. Incidence density (ID)， early diagnosis rate， and survival rate were compared among participants with different characteristics， and a health economic evaluation was conducted based on direct screening costs. ［Results］ The baseline high-risk cohort included 2 492 individuals， with a total of 12 405 person-times screened. A total of 80 liver cancer cases were detected. There were 42 early-stage cases， yielding an early diagnosis rate of 52.5%. The incidence density in male was significantly higher than that in female， and a significant age-related increasing trend was observed. 5-year survival rate was 43.9%. The cost per detected case and per detected early-stage case were 52 150 yuan and 99 333 yuan， respectively， and the early detection cost coefficient (EDCI) was 1.57. ［Conclusion］ The liver cancer high-risk cohort screening in Sheyang County achieved high early diagnosis and 5-year survival rates， demonstrating favorable health economic value. |
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