| 巩秦黎,曾红梅,梁雪雪,等.2022年甘肃省武威市女性乳腺癌流行特征及2010—2022年变化趋势分析[J].中国肿瘤,2026,35(6):467-474. |
| 2022年甘肃省武威市女性乳腺癌流行特征及2010—2022年变化趋势分析 |
| Incidence and Mortality of Female Breast Cancer in Wuwei City of Gansu Province in 2022 and Trends from 2010 to 2022 |
| 投稿时间：2026-01-13 |
| DOI：10.11735/j.issn.1004-0242.2026.06.A006 |
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| 中文关键词: 乳腺癌 发病率 死亡率 趋势 甘肃 |
| 英文关键词:breast cancer incidence mortality trend Gansu |
| 基金项目:甘肃省科技计划联合科研基金项目（25JRRH009）；甘肃中医药大学研究生创新基金（2026CXCY-168） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2022年甘肃省武威市女性乳腺癌的流行情况及2010—2022年变化趋势。［方法］ 按照国家癌症中心制定的数据质量审核评价标准，对武威市符合质量控制标准要求的肿瘤登记点上报的乳腺癌发病、死亡和人口数据进行汇总分析，分地区、年龄组计算发病及死亡粗率及其中国人口标化率（简称中标率）和世界人口标化率（简称世标率）。采用Joinpoint线性回归模型计算2010—2022年女性乳腺癌发病率、死亡率的年度变化百分比（annual percentage change，APC）、平均年度变化百分比（average annual percentage change，AAPC）及95%置信区间（confidence interval，CI），分析乳腺癌发病和死亡趋势。［结果］ 2022年武威市女性乳腺癌新发病例数为248例，粗发病率为28.86/10万，中标发病率为18.80/10万，世标发病率为18.94/10万，0~74岁累积发病率为1.82%。其中，城市与农村地区女性乳腺癌中标发病率分别为17.18/10万和22.04/10万。2022年女性乳腺癌死亡病例67例，粗死亡率为7.80/10万，中标死亡率为4.48/10万，世标死亡率为4.85/10万，0~74岁累积死亡率为0.49%。城市和农村地区乳腺癌中标死亡率分别为4.23/10万和4.91/10万。2010—2022年武威市女性乳腺癌中标发病率呈下降趋势（AAPC=-3.26%，P=0.02）。粗死亡率在2010—2022年呈现下降趋势（AAPC=-8.99%，P=0.03），中标死亡率也呈下降趋势（AAPC=-9.16%，P=0.04）。［结论］ 2022年武威市女性乳腺癌发病位居女性恶性肿瘤发病谱前列，城乡发病与死亡水平存在差异。2010—2022年，女性乳腺癌中标发病率及死亡率均呈显著下降趋势，提示现有防控措施取得一定成效。未来仍需持续监测发病与死亡趋势，针对城乡差异优化防控策略，强化早筛早治，进一步降低疾病负担。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence and mortality of female breast cancer in Wuwei City of Gansu Province in 2022， and to examine its trends from 2010 to 2022. ［Methods］ Based on the data quality review and evaluation standards established by the National Cancer Center， data on breast cancer incidence， mortality， and population reported by qualified tumor registries in Wuwei City were aggregated and analyzed. Crude incidence/mortality rates， age-standardized incidence /mortality rate by Chinese standard population(ASIRC and ASMRC)， and age-standardi-zed incidence/mortality rate by world standard population(ASIRW and ASMRW) were calculated by region and age group. The Joinpoint linear regression model was used to compute the annual percentage change (APC)， average annual percentage change (AAPC)， and 95% confidence intervals(CI) for female breast cancer incidence and mortality in Wuwei from 2010 to 2022. ［Results］ In 2022， there were 248 new cases of female breast cancer in Wuwei City. The crude incidence rate was 28.86/105， the ASIRC and ASIRW were 18.80/105 and 18.94/105， respectively. The cumulative incidence rate of 0~74 years old was 1.82%. The ASIRC in urban and rural areas was 17.18/105 and 22.04/105， respectively. There were 67 deaths of female breast cancer， with a crude mortality rate of 7.80/105， an ASIRC of 4.48/105， and an ASIRW of 4.85/105. The cumulative mortality rate of 0~74 years old was 0.49%. The ASIRC for breast cancer mortality in urban and rural areas was 4.23/105 and 4.91/105， respectively. From 2010 to 2022， the overall ASIRC of female breast cancer in Wuwei showed a significant declining trend (AAPC=-3.26%， P=0.02). The crude mortality rate also declined significantly during this period (AAPC=-8.99%， P=0.03)， as did the ASMRC (AAPC=-9.16%， P=0.04). ［Conclusion］ In 2022， female breast cancer incidence in Wuwei City ranked among the top in the female cancer spectrum， with differences in incidence and mortality between urban and rural areas. From 2010 to 2022， the age-standardized incidence and mortality rates of female breast cancer in the city showed a significant downward trend， suggesting that existing prevention and control measures have achieved certain effects. |
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