| 王雅楠,徐 明,唐宇凡,等.患者来源肿瘤模型用于结直肠癌微环境动态模拟与精准治疗决策系统的研究进展[J].中国肿瘤,2026,35(5):404-414. |
| 患者来源肿瘤模型用于结直肠癌微环境动态模拟与精准治疗决策系统的研究进展 |
| Research Progress of Patient-Derived Tumor Models for Dynamic Simulation of Colorectal Cancer Microenvironment and Precision Treatment Decision-Making System |
| 投稿时间：2025-12-13 |
| DOI：10.11735/j.issn.1004-0242.2026.05.A009 |
|
 |
| 中文关键词: 结直肠癌 肿瘤微环境 类器官 临床前模型 异种移植 |
| 英文关键词:colorectal cancer tumor microenvironment organoids preclinical models xenograft |
| 基金项目:甘肃省自然科学基金（23JRRA539）；甘肃省科技计划（25JRRA1188）；甘肃省青年科技基金（25JRRA817） |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 摘 要：结直肠癌是全球发病率与死亡率均位居前列的恶性肿瘤，其治疗面临肿瘤异质性高、微环境介导的耐药性强以及易转移复发等严峻挑战。这些特性使得传统二维细胞系及动物模型在精准预测临床疗效方面存在显著局限。近年来，患者来源类器官（patient-derived organoids，PDOs）与患者来源异种移植（patient-derived xenograft，PDX）模型作为能够高度模拟原发肿瘤基因组特征、组织结构和微环境的新型模型，为结直肠癌研究带来了革命性突破。PDOs模型在体外实现了功能性药物筛选、靶向/免疫治疗反应评估、耐药机制解析及生物标志物发掘等方面的广泛应用；PDX模型则在体内完整生理环境下为药物疗效验证、转移过程研究和个体化治疗策略制定提供了关键平台。全文旨在系统综述PDOs与PDX模型在结直肠癌精准治疗领域的最新研究进展与应用价值，重点阐述其在药敏预测、机制探索及治疗策略开发中的重要作用。 |
| 英文摘要: |
| Abstract： Colorectal cancer is a malignant tumor with the highest morbidity and mortality worldwide， and its treatment faces severe challenges such as high tumor heterogeneity， strong microenvironment-mediated drug resistance， and easy metastasis and recurrence. These properties make traditional two-dimensional cell lines and animal models significantly limited in accurately predicting clinical efficacy. In recent years， patient-derived organoids (PDOs) and patient-derived xenograft (PDX) models have revolutionized colorectal cancer research as novel models that can highly mimic the genomic characteristics， tissue structure， and microenvironment of primary tumors. PDOs model have been widely used in functional drug screening， targeted/immunotherapy response evaluation， drug resistance mechanism analysis and biomarker excavation in vitro； PDX model provide a key platform for drug efficacy verification， metastatic process research and individualized treatment strategy development in a complete physiological environment in vivo. The aim of this paper is to systematically review the latest research progress and application value of PDOs and PDX models in the field of precise treatment of colorectal cancer， focusing on their important roles in drug susceptibility prediction， mechanism exploration and treatment strategy development. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |